@article{fdi:010075155, title = {{A}lternative strategies for mosquito-borne arbovirus control}, author = {{A}chee, {N}. {L}. and {G}rieco, {J}. {P}. and {V}atandoost, {H}. and {S}eixas, {G}. and {P}into, {J}. and {C}hing-{N}g, {L}. and {M}artins, {A}. {J}. and {J}untarajumnong, {W}. and {C}orbel, {V}incent and {G}ouagna, {C}. and {D}avid, {J}. {P}. and {L}ogan, {J}. {G}. and {O}rsborne, {J}. and {M}arois, {E}. and {D}evine, {G}. {J}. and {V}ontas, {J}.}, editor = {}, language = {{ENG}}, abstract = {{B}ackground {M}osquito-borne virusessuch as {Z}ika, chikungunya, dengue fever, and yellow fever, among othersare of global importance. {A}lthough vaccine development for prevention of mosquito-borne arbovirus infections has been a focus, mitigation strategies continue to rely on vector control. {H}owever, vector control has failed to prevent recent epidemics and arrest expanding geographic distribution of key arboviruses, such as dengue. {A}s a consequence, there has been increasing necessity to further optimize current strategies within integrated approaches and advance development of alternative, innovative strategies for the control of mosquito-borne arboviruses. {M}ethods and findings {T}his review, intended as a general overview, is one of a series being generated by the {W}orldwide {I}nsecticide resistance {N}etwork ({WIN}). {T}he alternative strategies discussed reflect those that are currently under evaluation for public health value by the {W}orld {H}ealth {O}rganization ({WHO}) and represent strategies of focus by globally recognized public health stakeholders as potential insecticide resistance ({IR})-mitigating strategies. {C}onditions where these alternative strategies could offer greatest public health value in consideration of mitigating {IR} will be dependent on the anticipated mechanism of action. {A}rguably, the most pressing need for endorsement of the strategies described here will be the epidemiological evidence of a public health impact. {C}onclusions {A}s the burden of mosquito-borne arboviruses, predominately those transmitted by {A}edes aegypti and {A}. albopictus, continues to grow at a global scale, new vector-control tools and integrated strategies will be required to meet public health demands. {D}ecisions regarding implementation of alternative strategies will depend on key ecoepidemiological parameters that each is intended to optimally impact toward driving down arbovirus transmission. {A}uthor summary {I}nternational public health workers are challenged by the burden of arthropod-borne viral diseases, to include mosquito-borne arboviruses transmitted by {A}edes aegypti and {A}. albopictus due in part to lack of sustainable vector control and insecticide resistance ({IR}), as well as the inability to scale up and sustain existing interventions for prevention of urban epidemics. {A}s a consequence, there has been increasing interest to advance the development of alternative methods. {T}his review provides a general overview of alternative vector-control strategies under development for the control of arbovirus mosquito vectors and highlights how each could offer innovative public health value. {C}onsiderations to regulations, acceptance, and sustainability are also provided.}, keywords = {{MONDE}}, booktitle = {}, journal = {{PL}o{S} {N}eglected {T}ropical {D}iseases}, volume = {13}, numero = {1}, pages = {e0006822 [22 p.]}, ISSN = {1935-2735}, year = {2019}, DOI = {10.1371/journal.pntd.0006822}, URL = {https://www.documentation.ird.fr/hor/fdi:010075155}, }