@article{fdi:010075149,
  title = {{M}c{S}wan : a joint site frequency spectrum method to detect and date selective sweeps across multiple population genomes},
  author = {{T}ournebize, {R}{\'e}mi and {P}oncet, {V}al{\'e}rie and {J}akobsson, {M}. and {V}igouroux, {Y}ves and {M}anel, {S}.},
  editor = {},
  language = {{ENG}},
  abstract = {{I}nferring the mode and tempo of natural selection helps further our understanding of adaptation to past environmental changes. {H}ere, we introduce {M}c{S}wan, a method to detect and date past and recent natural selection events in the case of a hard sweep. {T}he method is based on the comparison of site frequency spectra obtained under various demographic models that include selection. {M}c{S}wan demonstrated high power (high sensitivity and specificity) in capturing hard selective sweep events without requiring haplotype phasing. {I}t performed slightly better than {S}wee{D} when the recent effective population size was low and the genomic region was small. {W}e then applied our method to a {E}uropean ({CEU}) and an {A}frican ({LWK}) human re-sequencing data set. {M}ost hard sweeps were detected in the {CEU} population (96%). {M}oreover, hard sweeps in the {A}frican population were estimated to have occurred further back in time (mode: 43,625 years {BP}) compared to those of {E}uropeans (mode: 24,850 years {BP}). {M}ost of the estimated ages of hard sweeps in {E}uropeans were associated with the {L}ast {G}lacial {M}aximum and were enriched in immunity-associated genes.},
  keywords = {age of selection ; coalescent process ; high-performance computing ; human ; selective sweep ; site frequency spectrum ; {EUROPE} ; {AFRIQUE} ; {KENYA}},
  booktitle = {},
  journal = {{M}olecular {E}cology {R}esources},
  volume = {19},
  numero = {1},
  pages = {283--295},
  ISSN = {1755-098{X}},
  year = {2019},
  DOI = {10.1111/1755-0998.12957},
  URL = {https://www.documentation.ird.fr/hor/fdi:010075149},
}