Barakat F., Vansteelandt M., Triastuti A., Jargeat P., Jacquemin D., Graton J., Mejia K., Cabanillas B., Vendier L., Stigliani J. L., Haddad Mohamed, Fabre N. (2019). Thiodiketopiperazines with two spirocyclic centers extracted from Botryosphaeria mamane, an endophytic fungus isolated from Bixa orellana l. Phytochemistry, 158, p. 142-148. ISSN 0031-9422.
Titre du document
Thiodiketopiperazines with two spirocyclic centers extracted from Botryosphaeria mamane, an endophytic fungus isolated from Bixa orellana l
Année de publication
2019
Auteurs
Barakat F., Vansteelandt M., Triastuti A., Jargeat P., Jacquemin D., Graton J., Mejia K., Cabanillas B., Vendier L., Stigliani J. L., Haddad Mohamed, Fabre N.
Source
Phytochemistry, 2019,
158, p. 142-148 ISSN 0031-9422
Three thiodiketopiperazines, botryosulfuranols A-C (1-3) were isolated from the endophytic fungus Botryosphaeria mamane. The three compounds present sulfur atoms on alpha- and beta-positions of phenylalanine derived residues and unprecedented two spirocyclic centers at C-4 and C-2'. Their planar structures were determined by spectroscopic analysis and absolute configurations were achieved by X-ray diffraction analysis and ECD and NMR chemical shifts calculations. Botryosulfuranol A (1) was the most cytotoxic compound against four cancer cell lines (HT-29, HepG2, Caco-2, HeLa) and two healthy cell lines (IEC6, Vero) highlighting the importance of an electrophilic center for cell growth inhibition.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020]
;
Sciences du monde végétal [076]
;
Biotechnologies [084]
Description Géographique
PEROU
Localisation
Fonds IRD [F B010074948]
Identifiant IRD
fdi:010074948
