@article{fdi:010074945,
  title = {{M}olecular characterization and mapping of glucose-6-phosphate dehydrogenase ({G}6{PD}) mutations in the {G}reater {M}ekong subregion},
  author = {{B}ancone, {G}. and {M}enard, {D}. and {K}him, {N}. and {K}im, {S}. and {C}anier, {L}. and {N}guong, {C}. and {P}hommasone, {K}. and {M}ayxay, {M}. and {D}ittrich, {S}. and {V}ongsouvath, {M}. and {F}ievet, {N}adine and {L}e {H}esran, {J}ean-{Y}ves and {B}riand, {V}al{\'e}rie and {K}eomany, {S}. and {N}ewton, {P}. {N}. and {G}orsawun, {G}. and {T}ardy, {K}. and {C}hu, {C}. {S}. and {R}attanapalroj, {O}. and {D}ong, {L}. {T}. and {Q}uang, {H}. {H}. and {N}guyen, {T}. {U}. and {N}guyen, {T}. {N}. and {H}ien, {T}. {T}. and {K}alnoky, {M}. and {N}osten, {F}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {P}lasmodium vivax malaria elimination can only be achieved by the deployment of 8-aminoquinolines (primaquine and tafenoquine) in combination with {ACT} to kill both blood and liver-stage parasites. {H}owever, primaquine and the other 8-aminoquinolines cause dose-dependent haemolysis in subjects with {G}6{PD} deficiency, an {X}-linked disorder of red blood cells that is very common in populations living in tropical and subtropical areas. {I}n order to inform safer use of 8-aminoquinolines in the {G}reater {M}ekong {S}ubregion, a multi-centre study was carried out to assess the prevalence of {G}6{PD} deficiency and to identify the main {G}6{PD} variants in samples collected in {C}ambodia, {L}ao {PDR}, {M}yanmar, {T}hailand and {V}ietnam.{M}ethods {B}lood samples were collected in the five countries during {N}ational {M}alaria {S}urveys or during {P}opulation {S}urveys. {D}uring {P}opulation {S}urveys samples were characterized for {G}6{PD} phenotype using the {F}luorescent {S}pot {T}est. {S}amples were then genotyped for a panel of {G}6{PD} mutations.{R}esults{G}6{PD} deficiency was found to be common in the region with an overall mean prevalence of deficient or mutated hemizygous males of 14.0%, ranging from a mean 7.3% in {T}hailand, 8.1% in {L}ao {PDR}, 8.9% in {V}ietnam, 15.8% in {M}yanmar and 18.8% in {C}ambodia. {M}ahidol and {V}iangchan mutations were the most common and widespread variants found among the nine investigated.{C}onclusions{O}wing to the high prevalence of {G}6{PD} deficiency in the {G}reater {M}ekong {S}ubregion, strategies for vivax malaria elimination should include point-of-care {G}6{PD} testing (both qualitative and quantitative) to allow safe and wide treatment with 8-aminoquinolines.},
  keywords = {{CAMBODGE} ; {LAOS} ; {MYANMAR} ; {THAILANDE} ; {VIET} {NAM} ; {MEKONG} {REGION}},
  booktitle = {},
  journal = {{M}alaria {J}ournal},
  volume = {18},
  numero = {},
  pages = {art. 20 [15 p.]},
  ISSN = {1475-2875},
  year = {2019},
  DOI = {10.1186/s12936-019-2652-y},
  URL = {https://www.documentation.ird.fr/hor/fdi:010074945},
}