Publications des scientifiques de l'IRD

Bancone G., Menard D., Khim N., Kim S., Canier L., Nguong C., Phommasone K., Mayxay M., Dittrich S., Vongsouvath M., Fievet Nadine, Le Hesran Jean-Yves, Briand Valérie, Keomany S., Newton P. N., Gorsawun G., Tardy K., Chu C. S., Rattanapalroj O., Dong L. T., Quang H. H., Nguyen T. U., Nguyen T. N., Hien T. T., Kalnoky M., Nosten F. (2019). Molecular characterization and mapping of glucose-6-phosphate dehydrogenase (G6PD) mutations in the Greater Mekong subregion. Malaria Journal, 18, p. art. 20 [15 p.]. ISSN 1475-2875.

Titre du document
Molecular characterization and mapping of glucose-6-phosphate dehydrogenase (G6PD) mutations in the Greater Mekong subregion
Année de publication
2019
Type de document
Article référencé dans le Web of Science WOS:000456602100001
Auteurs
Bancone G., Menard D., Khim N., Kim S., Canier L., Nguong C., Phommasone K., Mayxay M., Dittrich S., Vongsouvath M., Fievet Nadine, Le Hesran Jean-Yves, Briand Valérie, Keomany S., Newton P. N., Gorsawun G., Tardy K., Chu C. S., Rattanapalroj O., Dong L. T., Quang H. H., Nguyen T. U., Nguyen T. N., Hien T. T., Kalnoky M., Nosten F.
Source
Malaria Journal, 2019, 18, p. art. 20 [15 p.] ISSN 1475-2875
Background Plasmodium vivax malaria elimination can only be achieved by the deployment of 8-aminoquinolines (primaquine and tafenoquine) in combination with ACT to kill both blood and liver-stage parasites. However, primaquine and the other 8-aminoquinolines cause dose-dependent haemolysis in subjects with G6PD deficiency, an X-linked disorder of red blood cells that is very common in populations living in tropical and subtropical areas. In order to inform safer use of 8-aminoquinolines in the Greater Mekong Subregion, a multi-centre study was carried out to assess the prevalence of G6PD deficiency and to identify the main G6PD variants in samples collected in Cambodia, Lao PDR, Myanmar, Thailand and Vietnam.Methods Blood samples were collected in the five countries during National Malaria Surveys or during Population Surveys. During Population Surveys samples were characterized for G6PD phenotype using the Fluorescent Spot Test. Samples were then genotyped for a panel of G6PD mutations.ResultsG6PD deficiency was found to be common in the region with an overall mean prevalence of deficient or mutated hemizygous males of 14.0%, ranging from a mean 7.3% in Thailand, 8.1% in Lao PDR, 8.9% in Vietnam, 15.8% in Myanmar and 18.8% in Cambodia. Mahidol and Viangchan mutations were the most common and widespread variants found among the nine investigated.ConclusionsOwing to the high prevalence of G6PD deficiency in the Greater Mekong Subregion, strategies for vivax malaria elimination should include point-of-care G6PD testing (both qualitative and quantitative) to allow safe and wide treatment with 8-aminoquinolines.
Plan de classement
Santé : généralités [050] ; Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
CAMBODGE ; LAOS ; MYANMAR ; THAILANDE ; VIET NAM ; MEKONG REGION
Localisation
Fonds IRD [F B010074945]
Identifiant IRD
fdi:010074945
Contact