%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A De Loma, J.
%A Tirado, N.
%A Ascui, F.
%A Levi, M.
%A Vahter, M.
%A Broberg, K.
%A Gardon, Jacques
%T Elevated arsenic exposure and efficient arsenic metabolism in indigenous women around Lake Popo Bolivia
%D 2019
%L fdi:010074925
%G ENG
%J Science of the Total Environment
%@ 0048-9697
%K Arsenic ; Methylation ; Bolivia ; Uru ; Aymara ; Quechua
%K BOLIVIE ; ANDES
%K POPO LAC
%M ISI:000455903400019
%P 179-186
%R 10.1016/j.scitotenv.2018.11.473
%U https://www.documentation.ird.fr/hor/fdi:010074925
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers19-02/010074925.pdf
%V 657
%W Horizon (IRD)
%X Elevated concentrations of inorganic arsenic, one of the most potent environmental toxicants and carcinogens, have been detected in well water around Lake Poopo, Bolivia This study aimed to assess human exposure to arsenic in villages around Lake Poopo and also to elucidate whether the metabolism and detoxification of arsenic in this population is as efficient as previously indicated in other Andean areas. We recruited 201 women from 10 villages around Lake Poopo. Arsenic exposure was determined as the sum concentration of arsenic metabolites (inorganic arsenic; monomethylarsonic acid, MMA; and dimethylarsinic acid, DMA) in urine (U-As), measured by HPLC-HG-ICP-MS. Efficiency of arsenic metabolism was assessed by the relative fractions of the urinary metabolites. The women had a wide variation in U-As (range 12-407 ug/L, median 65 mu g/L) and a markedly efficient metabolism of arsenic with low %MMA (median 7.7%, range: 2.2-18%) and high %DMA (80%, range: 54-91%) in urine. In multivariable-adjusted linear regression models, ethnicity (Aymara-Quechua vs. Uru), body weight, fish consumption and tobacco smoking were associated with urinary arsenic metabolite fractions. On average, the Uru women had 2.5 lower % (percentage unit) iAs, 22 lower %MMA and 4.7 higher %DMA compared with the Aymara-Quechua women. Our study identified several factors that may predict these women's arsenic methylation capacity, particularly ethnicity. Further studies should focus on mechanisms underlying these differences in arsenic metabolism efficiency, and its importance for the risk of arsenic-related health effects.
%$ 050 ; 054 ; 021 ; 038