@article{fdi:010074925,
  title = {{E}levated arsenic exposure and efficient arsenic metabolism in indigenous women around {L}ake {P}opo {B}olivia},
  author = {{D}e {L}oma, {J}. and {T}irado, {N}. and {A}scui, {F}. and {L}evi, {M}. and {V}ahter, {M}. and {B}roberg, {K}. and {G}ardon, {J}acques},
  editor = {},
  language = {{ENG}},
  abstract = {{E}levated concentrations of inorganic arsenic, one of the most potent environmental toxicants and carcinogens, have been detected in well water around {L}ake {P}oopo, {B}olivia {T}his study aimed to assess human exposure to arsenic in villages around {L}ake {P}oopo and also to elucidate whether the metabolism and detoxification of arsenic in this population is as efficient as previously indicated in other {A}ndean areas. {W}e recruited 201 women from 10 villages around {L}ake {P}oopo. {A}rsenic exposure was determined as the sum concentration of arsenic metabolites (inorganic arsenic; monomethylarsonic acid, {MMA}; and dimethylarsinic acid, {DMA}) in urine ({U}-{A}s), measured by {HPLC}-{HG}-{ICP}-{MS}. {E}fficiency of arsenic metabolism was assessed by the relative fractions of the urinary metabolites. {T}he women had a wide variation in {U}-{A}s (range 12-407 ug/{L}, median 65 mu g/{L}) and a markedly efficient metabolism of arsenic with low %{MMA} (median 7.7%, range: 2.2-18%) and high %{DMA} (80%, range: 54-91%) in urine. {I}n multivariable-adjusted linear regression models, ethnicity ({A}ymara-{Q}uechua vs. {U}ru), body weight, fish consumption and tobacco smoking were associated with urinary arsenic metabolite fractions. {O}n average, the {U}ru women had 2.5 lower % (percentage unit) i{A}s, 22 lower %{MMA} and 4.7 higher %{DMA} compared with the {A}ymara-{Q}uechua women. {O}ur study identified several factors that may predict these women's arsenic methylation capacity, particularly ethnicity. {F}urther studies should focus on mechanisms underlying these differences in arsenic metabolism efficiency, and its importance for the risk of arsenic-related health effects.},
  keywords = {{A}rsenic ; {M}ethylation ; {B}olivia ; {U}ru ; {A}ymara ; {Q}uechua ; {BOLIVIE} ; {ANDES} ; {POPO} {LAC}},
  booktitle = {},
  journal = {{S}cience of the {T}otal {E}nvironment},
  volume = {657},
  numero = {},
  pages = {179--186},
  ISSN = {0048-9697},
  year = {2019},
  DOI = {10.1016/j.scitotenv.2018.11.473},
  URL = {https://www.documentation.ird.fr/hor/fdi:010074925},
}