@article{fdi:010074904,
  title = {{G}enetically diverse {P}lasmodium falciparum infections, within-host competition and symptomatic malaria in humans},
  author = {{S}ondo, {P}. and {D}erra, {K}. and {L}ef{\`e}vre, {T}hierry and {D}iallo-{N}akanabo, {S}. and {T}arnagda, {Z}. and {Z}ampa, {O}. and {K}azienga, {A}. and {V}alea, {I}. and {S}orgho, {H}. and {O}uedraogo, {J}. {B}. and {G}uiguemde, {T}. {R}. and {T}into, {H}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}here is a large genetic diversity of {P}lasmodium falciparum strains that infect people causing diverse malaria symptoms. {T}his study was carried out to explore the effect of mixed-strain infections and the extent to which some specific {P}. falciparum variants are associated with particular malaria symptoms. {P}. falciparum isolates collected during pharmacovigilance study in {N}anoro, {B}urkina {F}aso were used to determine allelic variation in two polymorphic antigens of the merozoite surface (msp1 and msp2). {O}verall, parasite density did not increase with additional strains, suggesting the existence of within-host competition. {P}arasite density was influenced by msp1 allelic families with highest parasitaemia observed in {MAD}20 allelic family. {H}owever, when in mixed infections with allelic family {K}1, {MAD}20 could not grow to the same levels as it would alone, suggesting competitive suppression in these mixed infections. {H}ost age was associated with parasite density. {O}verall, older patients exhibited lower parasite densities than younger patients, but this effect varied with the genetic composition of the isolates for the msp1 gene. {T}here was no effect of msp1 and msp2 allelic family variation on body temperature. {H}aemoglobin level was influenced by msp2 family with patients harboring the {FC}27 allele showing lower haemoglobin level than mono-infected individuals by the 3{D}7 allele. {T}his study provides evidence that {P}. falciparum genetic diversity influenced the severity of particular malaria symptoms and supports the existence of within-host competition in genetically diverse {P}. falciparum.},
  keywords = {{BURKINA} {FASO}},
  booktitle = {},
  journal = {{S}cientific {R}eports - {N}ature},
  volume = {9},
  numero = {},
  pages = {art. 127 [9 p.]},
  ISSN = {2045-2322},
  year = {2019},
  DOI = {10.1038/s41598-018-36493-y},
  URL = {https://www.documentation.ird.fr/hor/fdi:010074904},
}