@article{fdi:010074885,
  title = {{I}nfluence of activity space on the association between neighborhood characteristics and dementia risk : results from the 3-{C}ity study cohort},
  author = {{L}etellier, {N}. and {C}arriere, {I}. and {G}utierrez, {L}. {A}. and {G}abelle, {A}. and {D}artigues, {J}. {F}. and {D}ufouil, {C}. and {H}elmer, {C}. and {C}adot, {E}mmanuelle and {B}err, {C}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground{S}ocioeconomic level of residential environment was found to influence cognitive performance. {H}owever, individuals from the same place of residence may be affected differently. {W}e aim to investigate for the first time the influence of individual activity space on the association between neighborhood socioeconomic status ({NSES}) and the risk of dementia.{M}ethods{I}n the frame of the {T}hree-{C}ity cohort, a {F}rench population-based study, we followed longitudinally (12years) 7009 participants aged over 65. {T}he activity space (i.e., the spatial area through which a person moves daily) was defined using two questions from {L}awton's {I}nstrumental {A}ctivities of {D}aily {L}iving scale ({G}oes shopping independently,{T}ravels alone), and one question about mobility restriction. {T}he survival analysis was performed using a {C}ox marginal model that takes into account intra-neighborhood correlations and includes a large number of potential confounders.{R}esults{A}mong people with a limited activity space (n=772, 11%), risk of dementia is increased in subjects living in a deprived area (characterized by high {GINI} index or low median income) compared to those living in more favored.{C}onclusion{T}his study shows that the individual activity space modifies the association between {NSES} and the risk of dementia providing a more complete picture of residential inequalities. {I}f confirmed in different populations, these findings suggest that people with limited activity space and living in a deprived neighborhood are particularly at risk and should be targeted for prevention.},
  keywords = {{C}ognitive aging ; {S}ocial health inequalities ; {L}iving environment ; {D}eprivation ; {L}ife-space mobility ; {FRANCE}},
  booktitle = {},
  journal = {{BMC} {G}eriatrics},
  volume = {19},
  numero = {1},
  pages = {art. 4 [11 p.]},
  ISSN = {1471-2318},
  year = {2019},
  DOI = {10.1186/s12877-018-1017-7},
  URL = {https://www.documentation.ird.fr/hor/fdi:010074885},
}