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Gidoin Cindy, Ujvari B., Thomas F., Roche Benjamin. (2018). How is the evolution of tumour resistance at organ-scale impacted by the importance of the organ for fitness ?. BMC Evolutionary Biology, 18, art. 185 [10 p.]. ISSN 1471-2148

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Lien direct chez l'éditeur doi:10.1186/s12862-018-1298-7

Titre
How is the evolution of tumour resistance at organ-scale impacted by the importance of the organ for fitness ?
Année de publication2018
Type de documentArticle référencé dans le Web of Science WOS:000452465900001
AuteursGidoin Cindy, Ujvari B., Thomas F., Roche Benjamin.
SourceBMC Evolutionary Biology, 2018, 18, p. art. 185 [10 p.]. p. art. 185 [10 p.] ISSN 1471-2148
RésuméBackgroundA strong variability in cancer incidence is observed between human organs. Recently, it has been suggested that the relative contribution of organs to organism fitness (reproduction or survival) could explain at least a part of the observed variation. The objective of this study is to investigate theoretically the main factors driving the evolution of tumour resistance mechanisms of organs when their relative contribution to organism fitness is considered. We use a population-scale model where individuals can develop a tumour in a key organ (i.e. in which even a small tumour can negatively impact organism fitness), an auxiliary organ (i.e. in which only a large tumour has a relatively significant impact) or both organs because of metastasis.ResultsOur simulations show that natural selection acts in two different ways to prevent cancer in a key and an auxiliary organs. In the key organ, the strategy mostly selected is the highest resistance and only a high cost of resistance mitigates this behavior. Inversely, we observe that a low resistance strategy can be selected in the auxiliary organ when the development of the tumour is slow and the effect of a large tumour on the mortality of the organism is relatively weak. Nevertheless, if the tumour can spread to a key organ, higher resistance strategies are selected in the auxiliary organ.ConclusionFinally, our study demonstrates that the relative contribution of organs to the organism fitness and the metastatic propensity of the tumour influence the evolution of tumour resistance at organ scale and should be considered by studies aiming to explain the variability in cancer incidence at organ-scale.
Plan de classementSanté : généralités [050] ; Sciences fondamentales / Techniques d'analyse et de recherche [020]
LocalisationFonds IRD [F B010074748]
Identifiant IRDfdi:010074748
Lien permanenthttp://www.documentation.ird.fr/hor/fdi:010074748

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