%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Sagaon Teyssier, Luis
%A Suzan-Monti, M.
%A Demoulin, B.
%A Capitant, C.
%A et al.
%T Uptake of PrEP and condom and sexual risk behavior among MSM during the ANRS IPERGAY trial
%D 2016
%L fdi:010074660
%G ENG
%J AIDS Care.Psychological and Sociomedical Aspects of AIDS/HIV
%@ 0954-0121
%K SIDA ; PREVENTION SANITAIRE ; COMPORTEMENT SEXUEL ; TRANSMISSION ; ENQUETE
%K HOMOSEXUALITE ; PRESERVATIF
%K FRANCE
%M ISI:000372894500009
%N S1 No Spécial AIDS Impact
%P 48-55
%R 10.1080/09540121.2016.1146653
%U https://www.documentation.ird.fr/hor/fdi:010074660
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers19-02/010074660.pdf
%V 28
%W Horizon (IRD)
%X The double-blind phase of the randomized ANRS IPERGAY trial, evaluating sexual activity-based oral HIV pre-exposure prophylaxis (PrEP), was conducted among high-risk men who have sex with men (MSM). Results showed an 86% (95% CI: 40-98) relative reduction in HIV incidence among participants with tenofovir disoproxil fumarate-emtricitabine vs. placebo. The present pooled analysis aimed to analyze (i) participants' adherence to the prescribed treatment and/or condom use during sexual intercourse and (ii) sexual behavior during the double-blind phase of the study. Four hundred MSM were enrolled in the trial. Every 2 months they completed online questionnaires collecting sexual behavior and PrEP adherence data regarding their most recent sexual intercourse. A total of 2232 questionnaires (M0-M24) were analyzed. Changes over time were evaluated using a mixed model accounting for multiple measures. Irrespective of sexual partner and practice type, on average, 42.6% (min: 32.1-max: 45.8%) reported PrEP use only during their most recent episode of sexual intercourse; 29% (22.9-35.6%) reported both PrEP and condom use; 11.7% (7.2-18.9%) reported condom-use only, and 16.7% (10.8-29.6%) reported no PrEP or condom use with no significant change during the study. Scheduled (i.e., correct) PrEP use was reported on average by 59.0% (47.2-68.5%) of those reporting PrEP use during their most recent sexual intercourse. Overall, 70.3% (65.3-79.4%) and 69.3% (58.3-75.4%) of participants reported, respectively, condomless anal and condomless receptive anal intercourse during their most recent sexual encounter without significant change during follow-up. Overall, on average 83.3% (min: 70.4-max: 89.2%) of participants protected themselves by PrEP intake or condom use or both during the trial, and no increase in at-risk sexual practices was observed. None of these indicators showed significant trend during the follow-up, although we found a tendency toward decrease (p = .19) of the median number of sexual partners strengthening the absence of behavioral disinhibition. On-demand PrEP within a comprehensive HIV prevention package could improve prevention in MSM.
%B AIDS Impact Conference Supplement
%8 2015
%$ 052MALTRA03 ; 056SOCSAN