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Seck A., Hichami A., Doucoure S., Agne F. D., Bassene H., Ba A., Sokhna Cheikh, Khan N. A., Samb A. (2018). Th1/Th2 dichotomy in obese women with gestational diabetes and their macrosomic babies. Journal of Diabetes Research, art. 8474617 [8 p.]. ISSN 2314-6745

Fichier PDF disponiblehttp://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers18-12/010074520.pdf[ PDF Link ]

Lien direct chez l'éditeur doi:10.1155/2018/8474617

Titre
Th1/Th2 dichotomy in obese women with gestational diabetes and their macrosomic babies
Année de publication2018
Type de documentArticle référencé dans le Web of Science WOS:000451190600001
AuteursSeck A., Hichami A., Doucoure S., Agne F. D., Bassene H., Ba A., Sokhna Cheikh, Khan N. A., Samb A.
SourceJournal of Diabetes Research, 2018, p. art. 8474617 [8 p.]. p. art. 8474617 [8 p.] ISSN 2314-6745
RésuméThe aim of the study was to assess T cell differentiation and the modulation of inflammatory cytokines in obese and gestational diabetes mellitus (GDM) women and their macrosomic newborns. Hence, immediately after delivery, blood samples were collected through the mother's arm vein and the umbilical cordon vein. Biochemical parameters measured were HbA1C, glucose, insulin, triglyceride (TG), total cholesterol (Tchol), HDL cholesterol (HDLchol), and LDL cholesterol (LDLchol). T lymphocytes were purified from the total blood with Ficoll-Paque. The mRNA expression of inflammatory markers in T cells was determined by RT-qPCR. We observed that diabetic mothers exhibited higher HbA1C, glycemia, insulinemia, TG, Tchol, HDLchol, and LDLchol levels than control mothers. Glycemia was not significantly different between macrosomic and control newborns. However, insulinemia was high in macrosomic babies. TG, Tchol, HDLchol, and LDLchol were not significantly different between macrosomic and control babies. In diabetic mothers, mRNA expression of the Th1 cell subtype was significantly increased. Th1 markers were upregulated in babies born to diabetic women than in control newborns. However, expression of two Th2 markers (GATA3 and IL-4) was not significantly different between control and GDM women and between their respective newborns. Interestingly, IL-10 mRNA expression was decreased in diabetic mothers and their offsprings. The Th1/Th2 cytokine ratio was increased in GDM obese mothers and their macrosomic newborns, suggesting a proinflammatory status in these subjects.
Plan de classementSanté : généralités [050]
Descr. géo.SENEGAL
LocalisationFonds IRD [F B010074520]
Identifiant IRDfdi:010074520
Lien permanenthttp://www.documentation.ird.fr/hor/fdi:010074520

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