@article{fdi:010074474,
  title = {{I}s adaptive therapy natural ?},
  author = {{T}homas, {F}. and {D}onnadieu, {E}. and {C}harriere, {G}. {M}. and {J}acqueline, {C}. and {T}asiemski, {A}. and {P}ujol, {P}. and {R}enaud, {F}. and {R}oche, {B}enjamin and {H}amede, {R}. and {B}rown, {J}. and {G}atenby, {R}. and {U}jvari, {B}.},
  editor = {},
  language = {{ENG}},
  abstract = {{R}esearch suggests that progression-free survival can be prolonged by integrating evolutionary principles into clinical cancer treatment protocols. {T}he goal is to prevent or slow the proliferation of resistant malignant cell populations. {T}he logic behind this therapy relies on ecological and evolutionary processes. {T}hese same processes would be available to natural selection in decreasing the probability of an organism's death due to cancer. {W}e propose that organisms' anticancer adaptions include not only ones for preventing cancer but also ones for directing and retarding the evolution of life-threatening cancer cells. {W}e term this last strategy natural adaptive therapy ({NAT}). {T}he body's {NAT} might include a lower than otherwise possible immune response. {A} restrained immune response might forego maximum short-term kill rates. {R}estraint would forestall immune-resistant cancer cells and produce long-term durable control of the cancer population. {H}ere, we define, develop, and explore the possibility of {NAT}. {T}he discovery of {NAT} mechanisms could identify new strategies in tumor prevention and treatments. {F}urthermore, we discuss the potential risks of immunotherapies that force the immune system to ramp up the short-term kill rates of malignant cancer cells in a manner that undermines the body's {NAT} and accelerates the evolution of immune resistance.},
  keywords = {},
  booktitle = {},
  journal = {{PL}o{S} {B}iology},
  volume = {16},
  numero = {10},
  pages = {e2007066 [12p.]},
  ISSN = {1545-7885},
  year = {2018},
  DOI = {10.1371/journal.pbio.2007066},
  URL = {https://www.documentation.ird.fr/hor/fdi:010074474},
}