@article{fdi:010074162,
  title = {{T}herapeutic potential of a new jumbo phage that infects {V}ibrio coralliilyticus, a widespread coral pathogen},
  author = {{J}acquemot, {L}. and {B}ettarel, {Y}van and {M}onjol, {J}. and {C}orre, {E}. and {H}alary, {S}. and {D}esnues, {C}. and {B}ouvier, {T}. and {F}errier-{P}ages, {C}. and {B}audoux, {A}. {C}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}iological control using bacteriophages is a promising approach for mitigating the devastating effects of coral diseases. {S}everal phages that infect {V}ibrio coralliilyticus, a widespread coral pathogen, have been isolated, suggesting that this bacterium is permissive to viral infection and is, therefore, a suitable candidate for treatment by phage therapy. {I}n this study, we combined functional and genomic approaches to evaluate the therapeutic potential of {BONAISHI}, a novel {V}. coralliilyticus phage, which was isolated from the coral reef in {V}an {P}hong {B}ay ({V}ietnam). {BONAISHI} appears to be strictly lytic for several pathogenic strains of {V}. coralliilyticus and remains infectious over a broad range of environmental conditions. {T}his candidate has an unusually large ds{DNA} genome (303 kb), with no genes that encode known toxins or implicated in lysogeny control. {W}e identified several proteins involved in host lysis, which may offer an interesting alternative to the use of whole bacteriophages for controlling {V}. coralliilyticus. {A} preliminary therapy test showed that adding {BONAISHI} to an infected culture of {S}ymbiodinium sp. cells reduced the impact of {V}. coralliilyticus on {S}ymbiodinium sp. photosynthetic activity. {T}his study showed that {BONAISHI} is able to mitigate {V}. coralliilyticus infections, making it a good candidate for phage therapy for coral disease.},
  keywords = {phage therapy ; coral disease ; {V}ibrio coralliilyticus ; viral genomics ; phage-host interactions ; {VIET} {NAM} ; {VAN} {PHONG} {BAIE} ; {PACIFIQUE}},
  booktitle = {},
  journal = {{F}rontiers in {M}icrobiology},
  volume = {9},
  numero = {},
  pages = {art. 2501 [16 p.]},
  ISSN = {1664-302{X}},
  year = {2018},
  DOI = {10.3389/fmicb.2018.02501},
  URL = {https://www.documentation.ird.fr/hor/fdi:010074162},
}