Publications des scientifiques de l'IRD

Loy D. E., Plenderleith L. J., Sundararaman S. A., Liu W. M., Gruszczyk J., Chen Y. J., Trimboli S., Learn G. H., MacLean O. A., Morgan A. L. K., Li Y. Y., Avitto A. N., Giles J., Calvignac-Spencer S., Sachse A., Leendertz F. H., Speede S., Ayouba Ahidjo, Peeters Martine, Rayner J. C., Tham W. H., Sharp P. M., Hahn B. H. (2018). Evolutionary history of human Plasmodium vivax revealed by genome-wide analyses of related ape parasites. Proceedings of the National Academy of Sciences of the United States of America, 115 (36), p. E8450-E8459. ISSN 0027-8424.

Titre du document
Evolutionary history of human Plasmodium vivax revealed by genome-wide analyses of related ape parasites
Année de publication
2018
Type de document
Article référencé dans le Web of Science WOS:000443555000018
Auteurs
Loy D. E., Plenderleith L. J., Sundararaman S. A., Liu W. M., Gruszczyk J., Chen Y. J., Trimboli S., Learn G. H., MacLean O. A., Morgan A. L. K., Li Y. Y., Avitto A. N., Giles J., Calvignac-Spencer S., Sachse A., Leendertz F. H., Speede S., Ayouba Ahidjo, Peeters Martine, Rayner J. C., Tham W. H., Sharp P. M., Hahn B. H.
Source
Proceedings of the National Academy of Sciences of the United States of America, 2018, 115 (36), p. E8450-E8459 ISSN 0027-8424
Wild-living African apes are endemically infected with parasites that are closely related to human Plasmodium vivax, a leading cause of malaria outside Africa. This finding suggests that the origin of P. vivax was in Africa, even though the parasite is now rare in humans there. To elucidate the emergence of human P. vivax and its relationship to the ape parasites, we analyzed genome sequence data of P. vivax strains infecting six chimpanzees and one gorilla from Cameroon, Gabon, and Cote d'Ivoire. We found that ape and human parasites share nearly identical core genomes, differing by only 2% of coding sequences. However, compared with the ape parasites, human strains of P. vivax exhibit about 10-fold less diversity and have a relative excess of nonsynonymous nucleotide polymorphisms, with site-frequency spectra suggesting they are subject to greatly relaxed purifying selection. These data suggest that human P. vivax has undergone an extreme bottleneck, followed by rapid population expansion. Investigating potential host-specificity determinants, we found that ape P. vivax parasites encode intact orthologs of three reticulocyte-binding protein genes (rbp2d, rbp2e, and rbp3), which are pseudogenes in all human P. vivax strains. However, binding studies of recombinant RBP2e and RBP3 proteins to human, chimpanzee, and gorilla erythrocytes revealed no evidence of host-specific barriers to red blood cell invasion. These data suggest that, from an ancient stock of P. vivax parasites capable of infecting both humans and apes, a severely bottlenecked lineage emerged out of Africa and underwent rapid population growth as it spread globally.
Plan de classement
Entomologie médicale / Parasitologie / Virologie [052] ; Sciences du monde animal [080]
Description Géographique
AFRIQUE ; CAMEROUN ; GABON ; COTE D'IVOIRE
Localisation
Fonds IRD [F B010073985]
Identifiant IRD
fdi:010073985
Contact