@article{fdi:010073980,
  title = {{P}lasmodium vivax-like genome sequences shed new insights into {P}lasmodium vivax biology and evolution},
  author = {{G}ilabert, {A}. and {O}tto, {T}. {D}. and {R}utledge, {G}. {G}. and {F}ranzon, {B}. and {O}llomo, {B}. and {A}rnathau, {C}. and {D}urand, {P}. and {M}oukodoum, {N}. {D}. and {O}kouga, {A}. {P}. and {N}goubangoye, {B}. and {M}akanga, {B}. and {B}oundenga, {L}. and {P}aupy, {C}hristophe and {R}enaud, {F}. and {P}rugnolle, {F}. and {R}ougeron, {V}.},
  editor = {},
  language = {{ENG}},
  abstract = {{A}lthough {P}lasmodium vivax is responsible for the majority of malaria infections outside {A}frica, little is known about its evolution and pathway to humans. {I}ts closest genetic relative, {P}. vivax-like, was discovered in {A}frican great apes and is hypothesized to have given rise to {P}. vivax in humans. {T}o unravel the evolutionary history and adaptation of {P}. vivax to different host environments, we generated using long- and short-read sequence technologies 2 new {P}. vivax-like reference genomes and 9 additional {P}. vivax-like genotypes. {A}nalyses show that the genomes of {P}. vivax and {P}. vivax-like are highly similar and colinear within the core regions. {P}hylogenetic analyses clearly show that {P}. vivax-like parasites form a genetically distinct clade from {P}. vivax. {C}oncerning the relative divergence dating, we show that the evolution of {P}. vivax in humans did not occur at the same time as the other agents of human malaria, thus suggesting that the transfer of {P}lasmodium parasites to humans happened several times independently over the history of the {H}omo genus. {W}e further identify several key genes that exhibit signatures of positive selection exclusively in the human {P}. vivax parasites. {T}wo of these genes have been identified to also be under positive selection in the other main human malaria agent, {P}. falciparum, thus suggesting their key role in the evolution of the ability of these parasites to infect humans or their anthropophilic vectors. {F}inally, we demonstrate that some gene families important for red blood cell ({RBC}) invasion (a key step of the life cycle of these parasites) have undergone lineage-specific evolution in the human parasite (e.g., reticulocyte-binding proteins [{RBP}s]).},
  keywords = {},
  booktitle = {},
  journal = {{PL}o{S} {B}iology},
  volume = {16},
  numero = {8},
  pages = {e2006035 [25 p.]},
  ISSN = {1545-7885},
  year = {2018},
  DOI = {10.1371/journal.pbio.2006035},
  URL = {https://www.documentation.ird.fr/hor/fdi:010073980},
}