@article{fdi:010073965,
  title = {{I}ncidence and clinical outcomes of diabetes mellitus in {HIV}-infected adults in {T}hailand : a retrospective cohort study},
  author = {{P}aengsai, {N}. and {J}ourdain, {G}onzague and {C}haiwarith, {R}. and {T}antraworasin, {A}. and {B}owonwatanuwong, {C}. and {B}hakeecheep, {S}. and {C}ressey, {T}. {R}. and {M}ary, {J}. {Y}. and {S}alvadori, {N}icolas and {K}osachunhanun, {N}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {S}ince 2005, {T}hailand has scaled up one of the largest antiretroviral treatment ({ART}) programs in {S}outh {E}ast {A}sia. {A}lthough diabetes mellitus ({DM}) incidence is increasing in low and middle-income countries, its burden and contributing factors in the {HIV} infected population are not well known. {M}ethods: {U}sing the {T}hai {N}ational {AIDS} {P}rogram data over a period of 8-years, we identified patients diagnosed with {DM} based on the following records: 1) fasting plasma glucose equal to or greater than 126 mg/dl following the 2013 {A}merican {D}iabetes {A}ssociation criteria or 2) diagnosis codes {E}11-{E}14 of the 2010 {WHO} {I}nternational {C}lassification of {D}iseases, or 3) anti-diabetic drugs. {I}ncidence was the number of new cases divided by that of person-years of follow-up ({PYFU}). {C}ompeting risks survival regression, treating death without {DM} as a competing event, was used to identify factors associated with {DM}. {T}he risk of death in patients diagnosed with {DM} was estimated using {C}ox regression models. {R}esults: {D}ata of 763,666 {PYFU} from 199,707 patients (54.2% male; median age 36.2 years at registration with the program) were available and 8383 cases were diagnosed with {DM}, resulting in an incidence rate of 11.0 per 1000 {PYFU}. {N}ew {DM} diagnosis was more likely in men (adjusted sub-distribution hazard ratio 1.2), older patients (compared to patients 18 to 34 years old: 1.8 for 35 to 44; 3.0 for 45 to 59; 3.8 for >= 60), and if {ART} was initiated (1.3). {I}n 2014, 1313 (16.6%) of 7905 diabetic patients had {DM} complications (11.5% microvascular complications and 6.9% macrovascular complications). {P}atients diagnosed with {DM} were at higher risk of death compared to the others. {C}onclusions: {DM} incidence was higher in this {T}hailand cohort of {HIV} infected adults than in the general population. {R}isk factors were similar to those in the general population, in addition to starting {ART}.},
  keywords = {{HIV} infection ; {A}ntiretroviral treatment ; {D}iabetes mellitus ; {I}ncidence ; {D}iabetic complications ; {THAILANDE}},
  booktitle = {},
  journal = {{BMC} {P}ublic {H}ealth},
  volume = {18},
  numero = {},
  pages = {art. 1079 [10 p.]},
  ISSN = {1471-2458},
  year = {2018},
  DOI = {10.1186/s12889-018-5967-7},
  URL = {https://www.documentation.ird.fr/hor/fdi:010073965},
}