@article{fdi:010073885,
  title = {{C}ellular immune response to {P}lasmodium falciparum after pregnancy is related to previous placental infection and parity},
  author = {{F}ievet, {N}adine and {T}ami, {G}. and {M}aubert, {B}. and {M}oussa, {M}. and {S}haw, {I}. and {C}ot, {M}ichel and {H}older, {A}. and {C}haouat, {G}. and {D}eloron, {P}hilippe},
  editor = {},
  language = {{ENG}},
  abstract = {{BACKGROUND}: {M}alaria in pregnancy is characterised by the sequestration of {P}lasmodium falciparum-infected erythrocytes in placental intervillous spaces. {P}lacental parasites express a specific phenotype, which allows them to cytoadhere to chondroitin sulfate {A} expressed by syncytiotrophoblasts. {M}alaria infection during pregnancy allows the acquisition of antibodies against placental parasites, these antibodies are thought to be involved in protection during subsequent pregnancies. {METHODS}: {T}o investigate the development of a cellular response to placental parasites during pregnancy, peripheral blood mononuclear cells were collected from women at the time of their confinement. {T}he study was performed in {C}ameroon where malaria transmission is perennial. {I}n vitro cell proliferation and cytokine production were measured in response to non-malarial activators (concanavalin {A} and {PPD}), a recombinant protein from {P}. falciparum {MSP}-1, and erythrocytes infected by two {P}. falciparum lines, {RP}5 and {W}2. {L}ike placental parasites, the {RP}5 line, but not {W}2, adheres to chondroitin sulfate {A} and to syncytiotrophoblasts. {RESULTS}: {T}he proliferative response to all antigens was lower for cells obtained at delivery than 3 months later. {M}ost interestingly, the cellular response to the {RP}5 line of {P}. falciparum was closely related to parity. {T}he prevalence rate and the levels of response gradually increased with the number of previous pregnancies. {N}o such relationship was observed with {W}2 line, or {MSP}-1 antigen. {CONCLUSIONS}: {T}his suggests the occurrence of an immune response more specific for the {RP}5 line in women having had multiple pregnancies, and who are likely to develop immunity to pregnancy-associated parasites. {B}oth humoral and cellular mechanisms may account for the lower susceptibility of multigravidae to malaria.},
  keywords = {{CAMEROUN}},
  booktitle = {},
  journal = {{M}alaria {J}ournal},
  volume = {1},
  numero = {},
  pages = {art. no 16 [8 ]},
  year = {2002},
  DOI = {10.1186/1475-2875-1-16},
  URL = {https://www.documentation.ird.fr/hor/fdi:010073885},
}