@article{fdi:010073791,
  title = {{M}ini-review on {CRISPR}-{C}as9 and its potential applications to help controlling neglected tropical diseases caused by {T}rypanosomatidae},
  author = {{M}inet, {C}. and {T}hevenon, {S}. and {C}hantal, {I}. and {S}olano, {P}hilippe and {B}erthier, {D}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he {CRISPR}-{C}as system, which was originally identified as a prokaryotic defense mechanism, is increasingly being used for the functional study of genes. {T}his technology, which is simple, inexpensive and efficient, has aroused a lot of enthusiasm in the scientific community since its discovery, and every month many publications emanate from very different communities reporting on the use of {CRISPR}-{C}as9. {C}urrently, there are no vaccines to control neglected tropical diseases ({NTD}s) caused by {T}rypanosomatidae, particularly {H}uman {A}frican {T}rypanosomiasis ({HAT}) and {A}nimal {A}frican {T}rypanosomoses ({AAT}), and treatments are cumbersome and sometimes not effective enough. {CRISPR}-{C}as9 has the potential to functionally analyze new target molecules that could be used for therapeutic and vaccine purposes. {I}n this review, after briefly describing {CRIPSR}-{C}as9 history and how it works, different applications on diseases, especially on parasitic diseases, are reviewed. {W}e then focus the review on the use of {CRISPR}-{C}as9 editing on {T}rypanosomatidae parasites, the causative agents of {NTD}s, which are still a terrible burden for human populations in tropical regions, and their vectors.},
  keywords = {{CRISPR}-{C}as9 ; {T}rypanosomatidae ; {P}arasites ; {N}eglected tropical diseases ; {AFRIQUE} {SUBSAHARIENNE} ; {ZONE} {TROPICALE}},
  booktitle = {},
  journal = {{I}nfection {G}enetics and {E}volution},
  volume = {63},
  numero = {},
  pages = {326--331},
  ISSN = {1567-1348},
  year = {2018},
  DOI = {10.1016/j.meegid.2018.02.030},
  URL = {https://www.documentation.ird.fr/hor/fdi:010073791},
}