@article{fdi:010073779,
  title = {{A}daptive deletion in resistance gene duplications in the malaria vector {A}nopheles gambiae},
  author = {{A}ssogba, {B}. {S}. and {A}lout, {H}. and {K}offi, {A}. and {P}ennetier, {C}{\'e}dric and {D}jogbenou, {L}. {S}. and {M}akoundou, {P}. and {W}eill, {M}. and {L}abbe, {P}.},
  editor = {},
  language = {{ENG}},
  abstract = {{W}hile gene copy-number variations play major roles in long-term evolution, their early dynamics remains largely unknown. {H}owever, examples of their role in short-term adaptation are accumulating: identical repetitions of a locus (homogeneous duplications) can provide a quantitative advantage, while the association of differing alleles (heterogeneous duplications) allows carrying two functions simultaneously. {S}uch duplications often result from rearrangements of sometimes relatively large chromosome fragments, and even when adaptive, they can be associated with deleterious side effects that should, however, be reduced by subsequent evolution. {H}ere, we took advantage of the unique model provided by the malaria mosquito {A}nopheles gambiae s.l. to investigate the early evolution of several duplications, heterogeneous and homogeneous, segregating in natural populations from {W}est {A}frica. {T}hese duplications encompass 200kb and 11 genes, including the adaptive insecticide resistance ace-1 locus. {T}hrough the survey of several populations from three countries over 3-4years, we showed that an internal deletion of all coamplified genes except ace-1 is currently spreading in {W}est {A}frica and introgressing from {A}n.gambiae s.s. to {A}n. coluzzii. {B}oth observations provide evidences of its selection, most likely due to reducing the gene-dosage disturbances caused by the excessive copies of the nonadaptive genes. {O}ur study thus provides a unique example of the early adaptive trajectory of duplications and underlines the role of the environmental conditions (insecticide treatment practices and species ecology). {I}t also emphasizes the striking diversity of adaptive responses in these mosquitoes and reveals a worrisome process of resistance/cost trade-off evolution that could impact the control of malaria vectors in {A}frica.},
  keywords = {adaptive trajectory ; fitness cost ; gene duplication ; genome evolution ; insecticide resistance ; malaria vector ; {BENIN} ; {TOGO} ; {COTE} {D}'{IVOIRE}},
  booktitle = {},
  journal = {{E}volutionary {A}pplications},
  volume = {11},
  numero = {8},
  pages = {1245--1256},
  ISSN = {1752-4571},
  year = {2018},
  DOI = {10.1111/eva.12619},
  URL = {https://www.documentation.ird.fr/hor/fdi:010073779},
}