@article{fdi:010073740,
  title = {{S}pecific human antibody responses to {A}edes aegypti and {A}edes polynesiensis saliva : a new epidemiological tool to assess human exposure to disease vectors in the {P}acific},
  author = {{M}athieu-{D}aud{\'e}, {F}ran{\c{c}}oise and {C}laverie, {A}. and {P}lichart, {C}. and {B}oulanger, {D}enis and {M}phande, {F}. {A}. and {B}ossin, {H}. {C}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {A}edes mosquitoes severely affect the health and wellbeing of human populations by transmitting infectious diseases. {I}n {F}rench {P}olynesia, {A}edes aegypti is the main vector of dengue, chikungunya and {Z}ika, and {A}edes polynesiensis the primary vector of {B}ancroftian filariasis and a secondary vector of arboviruses. {T}ools for assessing the risk of disease transmission or for measuring the efficacy of vector control programmes are scarce. {A} promising approach to quantify the human-vector contact relies on the detection and the quantification of antibodies directed against mosquito salivary proteins. {M}ethodology/{P}rincipal findings {A}n {ELISA} test was developed to detect and quantify the presence of immunoglobulin {G} ({I}g{G}) directed against proteins from salivary gland extracts ({SGE}) of {A}e. aegypti and {A}e. polynesiensis in human populations exposed to either species, through a cross-sectional study. {I}n {T}ahiti and {M}oorea islands where {A}e. aegypti and {A}e. polynesiensis are present, the test revealed that 98% and 68% of individuals have developed {I}g{G} directed against {A}e. aegypti and {A}e. polynesiensis {SGE}, respectively. {B}y comparison, {ELISA} tests conducted on a cohort of people from metropolitan {F}rance, not exposed to these {A}edes mosquitoes, indicated that 97% of individuals had no {I}g{G} directed against {SGE} of either mosquito species. {T}he analysis of additional cohorts representing different entomological {A}edes contexts showed no {ELISA} {I}g{G} cross-reactivity between {A}e. aegypti and {A}e. polynesiensis {SGE}. {C}onclusions/{S}ignificance {T}he {I}g{G} response to salivary gland extracts seems to be a valid and specific biomarker of human exposure to the bites of {A}e. aegypti and {A}e. polynesiensis. {T}his new immunoepidemiological tool will enhance our understanding of people exposure to mosquito bites, facilitate the identification of areas where disease transmission risk is high and permit to evaluate the efficacy of novel vector control strategies in {P}acific islands and other tropical settings.},
  keywords = {{POLYNESIE} {FRANCAISE} ; {NOUVELLE} {CALEDONIE} ; {FRANCE} ; {BOLIVIE} ; {REUNION} ; {MARTINIQUE}},
  booktitle = {},
  journal = {{PL}o{S} {N}eglected {T}ropical {D}iseases},
  volume = {12},
  numero = {7},
  pages = {art. e0006660 [16 ]},
  ISSN = {1935-2735},
  year = {2018},
  DOI = {10.1371/journal.pntd.0006660},
  URL = {https://www.documentation.ird.fr/hor/fdi:010073740},
}