@article{fdi:010073729,
  title = {{B}radyrhizobium {L}ipid {A} : immunological properties and molecular basis of its binding to the myeloid differentiation protein-2/toll-like receptor 4 complex},
  author = {{L}embo-{F}azio, {L}. and {B}illod, {J}. {M}. and {D}i {L}orenzo, {F}. and {P}aciello, {I}. and {P}allach, {M}. and {V}az-{F}rancisco, {S}. and {H}olgado, {A}. and {B}eyaert, {R}. and {F}resno, {M}. and {S}himoyama, {A}. and {L}anzetta, {R}. and {F}ukase, {K}. and {G}ully, {D}jamel and {G}iraud, {E}ric and {M}artin-{S}antamaria, {S}. and {B}ernardini, {M}. {L}. and {S}ilipo, {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{L}ipopolysaccharides ({LPS}) are potent activator of the innate immune response through the binding to the myeloid differentiation protein-2 ({MD}-2)/toll-like receptor 4 ({TLR}4) receptor complexes. {A}lthough a variety of {LPS}s have been characterized so far, a detailed molecular description of the structure-activity relationship of the lipid {A} part has yet to be clarified. {P}hotosynthetic {B}radyrhizobium strains, symbiont of {A}eschynomene legumes, express distinctive {LPS}s bearing very long-chain fatty acids with a hopanoid moiety covalently linked to the lipid {A} region. {H}ere, we investigated the immunological properties of {LPS}s isolated from {B}radyrhizobium strains on both murine and human immune systems. {W}e found that they exhibit a weak agonistic activity and, more interestingly, a potent inhibitory effect on {MD}-2/{TLR}4 activation exerted by toxic enterobacterial {LPS}s. {B}y applying computational modeling techniques, we also furnished a plausible explanation for the {B}radyrhizobium {LPS} inhibitory activity at atomic level, revealing that its uncommon lipid {A} chemical features could impair the proper formation of the receptorial complex, and/or has a destabilizing effect on the pre-assembled complex itself.},
  keywords = {lipopolysaccharide ; innate immunity ; inflammatory cytokines ; myeloid ; differentiation protein-2/toll-like receptor 4 ; {B}radyrhizobium lipid {A} ; molecular modeling},
  booktitle = {},
  journal = {{F}rontiers in {I}mmunology},
  volume = {9},
  numero = {},
  pages = {art. 1888 [14 p.]},
  ISSN = {1664-3224},
  year = {2018},
  DOI = {10.3389/fimmu.2018.01888},
  URL = {https://www.documentation.ird.fr/hor/fdi:010073729},
}