@article{fdi:010073656,
  title = {{A} genome scan for genes underlying adult body size differences between {C}entral {A}frican hunter-gatherers and farmers},
  author = {{P}emberton, {T}. {J}. and {V}erdu, {P}. and {B}ecker, {N}. {S}. and {W}iller, {C}. {J}. and {H}ewlett, {B}. {S}. and {L}e {B}omin, {S}. and {F}roment, {A}lain and {R}osenberg, {N}. {A}. and {H}eyer, {E}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he evolutionary and biological bases of the {C}entral {A}frican "pygmy" phenotype, a characteristic of rainforest hunter-gatherers defined by reduced body size compared with neighboring farmers, remain largely unknown. {H}ere, we perform a joint investigation in {C}entral {A}frican hunter-gatherers and farmers of adult standing height, sitting height, leg length, and body mass index ({BMI}), considering 358 hunter-gatherers and 169 farmers with genotypes for 153,798 {SNP}s. {I}n addition to reduced standing heights, hunter-gatherers have shorter sitting heights and leg lengths and higher sitting/standing height ratios than farmers and lower {BMI} for males. {S}tanding height, sitting height, and leg length are strongly correlated with inferred levels of farmer genetic ancestry, whereas {BMI} is only weakly correlated, perhaps reflecting greater contributions of non-genetic factors to body weight than to height. {S}ingle- and multi-marker association tests identify one region and eight genes associated with hunter-gatherer/farmer status, and 24 genes associated with the height-related traits. {M}any of these genes have putative functions consistent with roles in determining their associated traits and the pygmy phenotype, and they include three associated with standing height in non-{A}fricans ({PRKG}1, {DSCAM}, {MAGI}2). {W}e find evidence that {E}uropean height-associated {SNP}s or variants in linkage disequilibrium with them contribute to standing- and sitting-height determination in {C}entral {A}fricans, but not to the differential status of hunter-gatherers and farmers. {T}hese findings provide new insights into the biological basis of the pygmy phenotype, and they highlight the potential of cross-population studies for exploring the genetic basis of phenotypes that vary naturally across populations.},
  keywords = {{CAMEROUN} ; {GABON} ; {CENTRAFRIQUE}},
  booktitle = {},
  journal = {{H}uman {G}enetics},
  volume = {137},
  numero = {6-7},
  pages = {487--509},
  ISSN = {0340-6717},
  year = {2018},
  DOI = {10.1007/s00439-018-1902-3},
  URL = {https://www.documentation.ird.fr/hor/fdi:010073656},
}