@article{fdi:010073609,
  title = {{A} metabolomic approach to identify anti-hepatocarcinogenic compounds from plants used traditionally in the treatment of liver diseases},
  author = {{C}hassagne, {F}. and {H}addad, {M}ohamed and {A}miel, {A}. and {P}hakeovilay, {C}. and {M}anithip, {C}. and {B}ourdy, {G}enevi{\`e}ve and {D}eharo, {E}ric and {M}arti, {G}.},
  editor = {},
  language = {{ENG}},
  abstract = {{L}iver cancer is a major health burden in {S}outheast {A}sia, and most patients turn towards the use of medicinal plants to alleviate their symptoms. {T}he aim of this work was to apply to {S}outheast {A}sian plants traditionally used to treat liver disorders, a successive ranking strategy based on a comprehensive review of the literature and metabolomic data in order to relate ethnopharmacological relevance to chemical entities of interest. {W}e analyzed 45 publications resulting in a list of 378 plant species, and our point system based on the frequency of citation in the literature allowed the selection of 10 top ranked species for further collection and extraction. {E}xtracts of these plants were tested for their in vitro anti-proliferative activities on {H}ep{G}2 cells. {E}thanolic extracts of {A}ndrographis paniculata, {O}roxylum indicum, {O}rthosiphon aristatus and {W}illughbeia edulis showed the highest anti-proliferative effects ({IC}50 = 195.9, 64.1, 71.3 and 66.7 mu g/ml, respectively). {A} metabolomic ranking model was performed to annotate compounds responsible for the anti-proliferative properties of {A}. paniculata (andrographolactone and dehydroandrographolide), {O}. indicum (baicalein, chrysin, oroxylin {A} and scutellarein), {O}. aristatus (5-desmethylsinensetin) and {W}. edulis (parabaroside {C} and procyanidin). {O}verall, our dereplicative approach combined with a bibliographic scoring system allowed us to rapidly decipher the molecular basis of traditionally used medicinal plants.},
  keywords = {{H}epatocellular carcinoma ; {M}edicinal plants ; {H}ep{G}2 ; {A}nti-proliferative effect ; {S}outheast {A}sia ; {M}etabolomics ; {ASIE} {DU} {SUD} {EST} ; {CAMBODGE} ; {LAOS} ; {VIET} {NAM} ; {THAILANDE} ; {CHINE}},
  booktitle = {},
  journal = {{F}itoterapia},
  volume = {127},
  numero = {},
  pages = {226--236},
  ISSN = {0367-326{X}},
  year = {2018},
  DOI = {10.1016/j.fitote.2018.02.021},
  URL = {https://www.documentation.ird.fr/hor/fdi:010073609},
}