@article{fdi:010073209,
  title = {{V}alue of chest {X}-ray in {TB} diagnosis in {HIV}-infected children living in resource-limited countries : the {ANRS} 12229-{PAANTHER} 01 study},
  author = {{B}erteloot, {L}. and {M}arcy, {O}. and {N}guyen, {B}. and {U}ng, {V}. and {T}ejiokem, {M}. and {N}acro, {B}. and {G}oyet, {S}. and {D}im, {B}. and {B}lanche, {S}. and {B}orand, {L}. and {M}sellati, {P}hilippe and {D}elacourt, {C}. and {ANRS} 12229 {PAANTHER} 01 {S}tudy {G}roup},
  editor = {},
  language = {{ENG}},
  abstract = {{OBJECTIVE}: {T}o evaluate inter-reader agreement and diagnostic accuracy of chest radiography ({CXR}) in the diagnosis of tuberculosis ({TB}) in children with human immunodeficiency virus ({HIV}) infection. {DESIGN}: {HIV}-infected children with clinically suspected {TB} were enrolled in a prospective study conducted in {B}urkina {F}aso, {C}ambodia, {C}ameroon and {V}iet {N}am from {A}pril 2010 to {D}ecember 2014. {T}hree readers-a local radiologist, a paediatric pulmonologist and a paediatric radiologist-independently reviewed the {CXR}s. {I}nter-reader agreement was then assessed using the kappa coefficient. {D}iagnostic accuracy of {CXR} was assessed in culture-confirmed cases and controls. {RESULTS}: {A} total of 403 children (median age 7.3 years, interquartile range 3.5-9.7; 49.6% males) were enrolled. {I}nter-reader agreement was as follows: between local radiologist and paediatric pulmonologist, kappa = 0.36 (95%{CI} 0.27-0.45); local radiologist and paediatric radiologist, kappa = 0.16 (95%{CI} 0.08-0.24); and paediatric pulmonologist and paediatric radiologist, kappa = 0.30 (95%{CI} 0.21-0.40). {A}mong 51 cases and 151 controls, after a consensus, {CXR} had a sensitivity of 71.4% (95%{CI} 58.8-84.1) and a specificity of 50.0% (95%{CI} 41.9-58.1). {A}lveolar opacities and enlarged lymph nodes on {CXR} had limited specificity for {TB} (64.7% and 70.2%, respectively). {M}iliary and/or nodular opacities patterns on {CXR} were more specific to {TB} (specificity 94.3%). {CONCLUSION}: {CXR} showed poor-to-fair inter-reader agreement and limited diagnostic accuracy for {TB} in {HIV}-infected children, likely due to comorbidities. {R}adiological criteria for this specific population require further investigation.},
  keywords = {{HIV} ; children ; tuberculosis ; diagnosis ; chest {X}-ray ; {BURKINA} {FASO} ; {CAMBODGE} ; {CAMEROUN} ; {VIET} {NAM}},
  booktitle = {},
  journal = {{I}nternational {J}ournal of {T}uberculosis and {L}ung {D}isease},
  volume = {22},
  numero = {8},
  pages = {844--850 +5 p.},
  ISSN = {1027-3719},
  year = {2018},
  DOI = {10.5588/ijtld.18.0122},
  URL = {https://www.documentation.ird.fr/hor/fdi:010073209},
}