@article{fdi:010073168, title = {{P}redicting the likelihood and intensity of mosquito infection from sex specific {P}lasmodium falciparum gametocyte density}, author = {{B}radly, {J}. and {S}tone, {W}. and {D}a, {D}. {F}. and {M}orlais, {I}sabelle and {D}icko, {A}. and {C}ohuet, {A}nna and {G}uelbeogo, {W}. {M}. and {M}ahamar, {A}. and {N}sango, {S}. and {S}oumare, {H}. {M}. and {D}iawara, {H}. and {L}anke, {K}. and {G}raumans, {W}. and {S}iebelink-{S}toter, {R}. and van de {V}egte-{B}olmer, {M}. and {C}hen, {I}. and {T}iono, {A}. and {G}oncalves, {B}. {P}. and {G}osling, {R}. and {S}auerwein, {R}. {W}. and {D}rakeley, {C}. and {C}hurcher, {T}. {S}. and {B}ousema, {T}.}, editor = {}, language = {{ENG}}, abstract = {{U}nderstanding the importance of gametocyte density on human-to-mosquito transmission is of immediate relevance to malaria control. {P}revious work ({C}hurcher et al., 2013) indicated a complex relationship between gametocyte density and mosquito infection. {H}ere we use data from 148 feeding experiments on naturally infected gametocyte carriers to show that the relationship is much simpler and depends on both female and male parasite density. {T}he proportion of mosquitoes infected is primarily determined by the density of female gametocytes though transmission from low gametocyte densities may be impeded by a lack of male parasites. {I}mproved precision of gametocyte quantification simplifies the shape of the relationship with infection increasing rapidly before plateauing at higher densities. {T}he mean number of oocysts per mosquito rises quickly with gametocyte density but continues to increase across densities examined. {T}he work highlights the importance of measuring both female and male gametocyte density when estimating the human reservoir of infection.}, keywords = {}, booktitle = {}, journal = {e{LIFE}}, volume = {7}, numero = {}, pages = {art. e34463 [13 ]}, ISSN = {2050-084{X}}, year = {2018}, DOI = {10.7554/e{L}ife.34463}, URL = {https://www.documentation.ird.fr/hor/fdi:010073168}, }