@article{fdi:010073123,
  title = {{T}he demographic history and mutational load of {A}frican hunter-gatherers and farmers},
  author = {{L}opez, {M}. and {K}ousathanas, {A}. and {Q}uach, {H}. and {H}armant, {C}. and {M}ouguiama-{D}aouda, {P}. and {H}ombert, {J}. {M}. and {F}roment, {A}lain and {P}erry, {G}. {H}. and {B}arreiro, {L}. {B}. and {V}erdu, {P}. and {P}atin, {E}. and {Q}uintana-{M}urci, {L}.},
  editor = {},
  language = {{ENG}},
  abstract = {{U}nderstanding how deleterious genetic variation is distributed across human populations is of key importance in evolutionary biology and medical genetics. {H}owever, the impact of population size changes and gene flow on the corresponding mutational load remains a controversial topic. {H}ere, we report high-coverage exomes from 300 rainforest hunter-gatherers and farmers of central {A}frica, whose distinct subsistence strategies are expected to have impacted their demographic pasts. {D}etailed demographic inference indicates that hunter-gatherers and farmers recently experienced population collapses and expansions, respectively, accompanied by increased gene flow. {W}e show that the distribution of deleterious alleles across these populations is compatible with a similar efficacy of selection to remove deleterious variants with additive effects, and predict with simulations that their present-day additive mutation load is almost identical. {F}or recessive mutations, although an increased load is predicted for hunter-gatherers, this increase has probably been partially counteracted by strong gene flow from expanding farmers. {C}ollectively, our predicted and empirical observations suggest that the impact of the recent population decline of {A}frican hunter-gatherers on their mutation load has been modest and more restrained than would be expected under a fully recessive model of dominance.},
  keywords = {{GABON} ; {CAMEROUN} ; {OUGANDA}},
  booktitle = {},
  journal = {{N}ature {E}cology and {E}volution},
  volume = {2},
  numero = {4},
  pages = {721--730},
  ISSN = {2397-334{X}},
  year = {2018},
  DOI = {10.1038/s41559-018-0496-4},
  URL = {https://www.documentation.ird.fr/hor/fdi:010073123},
}