@incollection{fdi:010072893,
  title = {{T}oward an ultimate explanation of intratumor heterogeneity},
  author = {{T}homas, {F}. and {U}jvari, {B}. and {G}idoin, {C}. and {T}asiemski, {A}. and {E}wald, {P}.{W}. and {R}oche, {B}enjamin},
  editor = {},
  language = {{ENG}},
  abstract = {{W}hile it is widely acknowledged that intratumor heterogeneity is mostly generated by genomic instability, we propose that genomic instability is only part of a proximate mechanism that maintains intratumor heterogeneity through oncogenic selection. {W}ithin tissues and organs, malignant cells achieve greater success by cooperating in the process of tumor construction, rather than by just being in isolation. {T}his process would involve the selection of a bet-hedging strategy during oncogenesis to generate the diversity of cell components needed to build, de novo, such an intricate cooperative system. {T}his process requires sufficient time to generate the diversity of relevant clones, which may explain why solid tumors tend to occur late in life. {I}n liquid environments, opportunities for structurally complex tumors are more limited. {T}his may help explain why cancer cells from liquid tumors generally do not aggregate, are on average less heterogeneous (i.e., low selection for bet-hedging), and can be detrimental early in life (e.g., leukemia). {I}n an evolutionary context, this suggests that the bet-hedging strategy is not only a universal risk-diversification strategy that evolves in the populations which face uncertain future and/or environment, it is also selected when there is a need of building, de novo, cooperative and complex systems.},
  keywords = {},
  booktitle = {{E}cology and evolution of cancer},
  numero = {},
  pages = {219--222},
  address = {{L}ondres},
  publisher = {{E}lsevier {A}cademic {P}ress},
  series = {},
  year = {2017},
  DOI = {10.1016/{B}978-0-12-804310-3.00017-{X}},
  ISBN = {978-0-12-804310-3},
  URL = {https://www.documentation.ird.fr/hor/fdi:010072893},
}