@article{fdi:010072856,
  title = {{E}xperimental design and solid state fermentation : a holistic approach to improve cultural medium for the production of fungal secondary metabolites},
  author = {{C}arboue, {Q}. and {C}laeys-{B}runo, {M}. and {B}ombarda, {I}. and {S}ergent, {M}. and {J}olain, {J}. and {R}oussos, {S}evastianos},
  editor = {},
  language = {{ENG}},
  abstract = {{S}olid-state fermentation ({SSF}) is a cultural method that holds tremendous potentials for the production of numerous microbial value-added compounds in various industries. {A}s for every other process, experimental designs can provide tools to improve the product yields, diminish the production time and thus eventually decreasing the cost of the whole process. {H}owever, {SSF}, because of its solid nature, implies some constraints which consequently require specific tools to efficiently overcome them. {T}he aim of this study was the improvement of the production of antioxidant naphtho-gamma-pyrones produced by {A}spergillus niger {G}131 cultivated using {SSF}. {T}wo experimental designs were presented, a combined design, taking into account two different types of variables to determine a proper solid medium, and a screening design with mixed-level factors to find solutes with significant positive effects on the output.},
  keywords = {{S}olid-state fermentation ; {E}xperimental design ; {A}spergillus niger ; {N}aphtho-gamma-pyrones},
  booktitle = {},
  journal = {{C}hemometrics and {I}ntelligent {L}aboratory {S}ystems},
  volume = {176},
  numero = {},
  pages = {101--107},
  ISSN = {0169-7439},
  year = {2018},
  DOI = {10.1016/j.chemolab.2018.03.011},
  URL = {https://www.documentation.ird.fr/hor/fdi:010072856},
}