@article{fdi:010072841, title = {{C}ohort profile : effect of malaria in early pregnancy on fetal growth in {B}enin ({RECIPAL} preconceptional cohort)}, author = {{A}ccrombessi, {M}. and {Y}ovo, {E}. and {C}ottrell, {G}illes and {A}gbota, {G}. and {G}artner, {A}gn{\`e}s and {M}artin-{P}r{\'e}vel, {Y}ves and {F}anou-{F}ogny, {N}. and {D}jossinou, {D}. and {Z}eitlin, {J}. and {T}uikue {N}dam, {N}icaise and {B}odeau-{L}ivinec, {F}. and {H}ouze, {S}. and {J}ackson, {N}. and {A}yemonna, {P}. and {M}assougbodji, {A}. and {C}ot, {M}ichel and {F}ievet, {N}adine and {B}riand, {V}al{\'e}rie}, editor = {}, language = {{ENG}}, abstract = {{P}urpose {RE}tard de {C}roissance {I}ntra-uterin et {PAL}udisme ({RECIPAL}) is an original preconceptional cohort designed to assess the consequences of malaria during the first trimester of pregnancy, which is a poorly investigated period in {A}frica and during which malaria may be detrimental to the fetus. {P}articipants {F}or this purpose, a total of 1214 women of reproductive age living in {S}o-{A}va and {A}kassato districts (south {B}enin) were followed up monthly from {J}une 2014 to {D}ecember 2016 until 411 of them became pregnant. {A} large range of health determinants was collected both before and during pregnancy from the first weeks of gestation to delivery. {F}ive {D}oppler ultrasound scans were performed for early dating of the pregnancy and longitudinal fetal growth assessment. {F}indings to date {P}regnant women were identified at a mean of 6.9 weeks of gestation (wg). {P}reliminary results confirmed the high prevalence of malaria in the first trimester of pregnancy, with more than 25.4% of women presenting at least one microscopic malarial infection during this period. {M}ost infections occurred before six wg. {T}he prevalence of low birth weight, small birth weight for gestational age (according to {INTERGROWTH}-21st charts) and preterm birth was 9.3%, 18.3% and 12.6%, respectively. {F}uture plans {RE}tard de {C}roissance {I}ntra-uterin et {PAL}udisme ({RECIPAL}) represents at this time a unique resource that will provide information on multiple infectious (including malaria), biological, nutritional and environmental determinants in relation to health outcomes in women of reproductive age, pregnant women and their newborns. {I}t will contribute to better define future recommendations for the prevention of malaria in early pregnancy and maternal malnutrition in {A}frica. {I}t confirms that it is possible to constitute a preconceptional pregnancy cohort in {A}frica and provides valuable information for researchers starting cohorts in the future.}, keywords = {{BENIN}}, booktitle = {}, journal = {{BMJ} {O}pen}, volume = {8}, numero = {1}, pages = {e019014 [13 ]}, ISSN = {2044-6055}, year = {2018}, DOI = {10.1136/bmjopen-2017-019014}, URL = {https://www.documentation.ird.fr/hor/fdi:010072841}, }