@article{fdi:010072833,
  title = {{O}xidative stress and neurodegeneration : the possible contribution of quinone reductase 2},
  author = {{C}assagnes, {L}. {E}. and {C}hhour, {M}. and {P}erio, {P}ierre and {S}udor, {J}. and {G}ayon, {R}. and {F}erry, {G}. and {B}outin, {J}. {A}. and {N}epveu, {F}. and {R}eybier, {K}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}here is increasing evidence that oxidative stress is involved in the etiology and pathogenesis of neurodegenerative disorders. {O}verproduction of reactive oxygen species ({ROS}) is due in part to the reactivity of catecholamines, such as dopamine, adrenaline, and noradrenaline. {T}hese molecules are rapidly converted, chemically or enzymatically, into catechol-quinone and then into highly deleterious semiquinone radicals after 1-electron reduction in cells. {N}otably, the overexpression of dihydronicotinamide riboside: quinone oxidoreductase ({QR}2) in {C}hinese hamster ovary ({CHO}) cells increases the production of {ROS}, mainly superoxide radicals, when it is exposed to exogenous catechol-quinones (e.g. dopachrome, aminochrome, and adrenochrome). {H}ere we used electron paramagnetic resonance analysis to demonstrate that the phenomenon observed in {CHO} cells is also seen in human leukemic cells ({K}562 cells) that naturally express {QR}2. {M}oreover, by manipulating the level of {QR}2 in neuronal cells, including immortalized neuroblast cells and ex vivo neurons isolated from {QR}2 knockout animals, we showed that there is a direct relationship between {QR}2-mediated quinone reduction and {ROS} overproduction. {S}upporting this result, the withdraw of the {QR}2 co-factor ({BNAH}) or the addition of the specific {QR}2 inhibitor {S}29434 suppressed oxidative stress. {T}aken together, these data suggest that the overexpression of {QR}2 in brain cells in the presence of catechol quinones might lead to {ROS}-induced cell death via the rapid conversion of superoxide radicals into hydrogen peroxide and then into highly reactive hydroxyl radicals. {T}hus, {QR}2 may be implicated in the early stages of neurodegenerative disorders.},
  keywords = {{QR}2 ; {C}atechol quinone ; {O}xidative stress ; {N}eurodegenerative disease ; {ROS} ; {R}edox cycle},
  booktitle = {},
  journal = {{F}ree {R}adical {B}iology and {M}edicine},
  volume = {120},
  numero = {},
  pages = {56--61},
  ISSN = {0891-5849},
  year = {2018},
  DOI = {10.1016/j.freeradbiomed.2018.03.002},
  URL = {https://www.documentation.ird.fr/hor/fdi:010072833},
}