@article{fdi:010072820,
  title = {{B}iochemistry and molecular biology of flaviviruses},
  author = {{B}arrows, {N}. {J}. and {C}ampos, {R}. {K}. and {L}iao, {K}. {C}. and {P}rasanth, {K}. {R}. and {S}oto-{A}costa, {R}. and {Y}eh, {S}. {C}. and {S}chott-{L}erner, {G}. and {P}ompon, {J}ulien and {S}essions, {O}. {M}. and {B}radrick, {S}. {S}. and {G}arcia-{B}lanco, {M}. {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{F}laviviruses, such as dengue, {J}apanese encephalitis, tick-borne encephalitis, {W}est {N}ile, yellow fever, and {Z}ika viruses, are critically important human pathogens that sicken a staggeringly high number of humans every year. {M}ost of these pathogens are transmitted by mosquitos, and not surprisingly, as the earth warms and human populations grow and move, their geographic reach is increasing. {F}laviviruses are simple {RNA}-protein machines that carry out protein synthesis, genome replication, and virion packaging in close association with cellular lipid membranes. {I}n this review, we examine the molecular biology of flaviviruses touching on the structure and function of viral components and how these interact with host factors. {T}he latter are functionally divided into pro-viral and antiviral factors, both of which, not surprisingly, include many {RNA} binding proteins. {I}n the interface between the virus and the hosts we highlight the role of a noncoding {RNA} produced by flaviviruses to impair antiviral host immune responses. {T}hroughout the review, we highlight areas of intense investigation, or a need for it, and potential targets and tools to consider in the important battle against pathogenic flaviviruses.},
  keywords = {},
  booktitle = {},
  journal = {{C}hemical {R}eviews},
  volume = {118},
  numero = {8},
  pages = {4448--4482},
  ISSN = {0009-2665},
  year = {2018},
  DOI = {10.1021/acs.chemrev.7b00719},
  URL = {https://www.documentation.ird.fr/hor/fdi:010072820},
}