@article{fdi:010072817,
  title = {{M}atched placental and circulating {P}lasmodium falciparum parasites are genetically homologous at the var2csa {ID}1-{DBL}2{X} locus by deep sequencing},
  author = {{W}altmann, {A}. and {P}atel, {J}. {C}. and {T}hwai, {K}. {L}. and {H}athaway, {N}. {J}. and {P}arobek, {C}. {M}. and {M}assougbodji, {A}. and {F}ievet, {N}adine and {B}ailey, {J}. {A}. and {D}eloron, {P}hilippe and {J}uliano, {J}. {J}. and {T}uikue {N}dam, {N}icaise and {M}eshnick, {S}. {R}.},
  editor = {},
  language = {{ENG}},
  abstract = {{I}n pregnancy-associated malaria, infected erythrocytes accumulate in the placenta. {I}t is unclear if in polyclonal infections this results in distinct peripheral and placental parasite populations. {W}e used long amplicon deep sequencing of {P}lasmodium falciparum var2csa {ID}1-{DBL}2{X} from 15 matched peripheral and placental samples collected at delivery from a high transmission area to determine genetic homology. {D}espite substantial sequence variation and detecting 23 haplotypes, the matched pairs mostly contained the same genetic variants, with 11 pairs sharing 100% of their variants, whereas others showed some heterogeneity. {T}hus, at delivery, peripheral and placental parasites appear to intermix and placental genotypes can be inferred through peripheral sampling.},
  keywords = {{BENIN}},
  booktitle = {},
  journal = {{A}merican {J}ournal of {T}ropical {M}edicine and {H}ygiene},
  volume = {98},
  numero = {1},
  pages = {77--82},
  ISSN = {0002-9637},
  year = {2018},
  DOI = {10.4269/ajtmh.17-0529},
  URL = {https://www.documentation.ird.fr/hor/fdi:010072817},
}