@article{fdi:010072772,
  title = {{S}oil-transmitted helminth infections and intestinal and systemic inflammation in schoolchildren},
  author = {de {G}ier, {B}. and {P}ita-{R}odriguez, {G}. {M}. and {C}ampos-{P}once, {M}. and van de {B}or, {M}. and {C}hamnan, {C}. and {J}unco-{D}iaz, {R}. and {D}oak, {C}. {M}. and {F}iorentino, {M}arion and {K}uong, {K}. and {A}ngel-{N}unez, {F}. and {P}arker, {M}. {E}. and {P}erignon, {M}. and {R}ojas-{R}ivero, {L}. and {B}erger, {J}acques and {P}olman, {K}. and {W}ieringa, {F}ranck},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he objective of this study was to assess whether soil-transmitted helminth ({STH}) infections are associated with systemic and local intestinal inflammation in school-age children. {I}n two studies in schoolchildren in {C}uba ({N} = 1389) and in {C}ambodia ({N} = 2471), {STH} infections and calprotectin concentrations were measured in stool samples and acute phase proteins {C}-reactive protein ({CRP}) and alpha-1 acid glycoprotein ({AGP}) were measured in blood. {A}ssociations between {STH} infections and elevated concentrations of {CRP}, {AGP} and calprotectin were estimated using multiple logistic regression. {T}he prevalence of elevated {CRP} concentration (>= 5 mg/{L}) was 5.4% in both populations. {E}levated {AGP} (>= 1 g/{L}) was found in 39.5% of the {C}ambodian children and 11.3% of the {C}uban children. {F}ecal calprotectin was elevated (>= 50 mg/kg) in 9.4% of the {C}ambodian children and 3.7% of the {C}uban children. {STH} infections in {C}uba were mainly due to {A}scaris lumbricoides and {T}richuris trichiura, with prevalences of 5.2% and 3.2%, respectively. {I}n {C}ambodia, hookworm was the most prevalent species (16.3%). {W}e found no significant associations between elevated concentrations of either acute phase proteins or fecal calprotectin and {STH} infections. {W}e observed a trend towards an inverse association between elevated {CRP} and {STH} infections in both studies. {STH} infections are not associated with either local intestinal or systemic inflammation. {T}he trend towards less elevated {CRP} concentration in {STH} infections may indicate a reduced risk of metabolic inflammatory diseases, which merits further investigation.},
  keywords = {{H}elminth ; {I}nflammation ; {C}-reactive protein ; {C}alprotectin ; {A}lpha-1 acid ; glycoprotein ; {CUBA} ; {CAMBODGE}},
  booktitle = {},
  journal = {{A}cta {T}ropica},
  volume = {182},
  numero = {},
  pages = {124--127},
  ISSN = {0001-706{X}},
  year = {2018},
  DOI = {10.1016/j.actatropica.2018.02.028},
  URL = {https://www.documentation.ird.fr/hor/fdi:010072772},
}