Soil-transmitted helminth infections and intestinal and systemic inflammation in schoolchildren - fdi:010072772 - Horizon

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de Gier B., Pita-Rodriguez G. M., Campos-Ponce M., van de Bor M., Chamnan C., Junco-Diaz R., Doak C. M., Fiorentino Marion, Kuong K., Angel-Nunez F., Parker M. E., Perignon M., Rojas-Rivero L., Berger Jacques, Polman K., Wieringa Franck. (2018). Soil-transmitted helminth infections and intestinal and systemic inflammation in schoolchildren. Acta Tropica, 182, 124-127. ISSN 0001-706X

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Lien direct chez l'éditeur doi:10.1016/j.actatropica.2018.02.028

Titre
Soil-transmitted helminth infections and intestinal and systemic inflammation in schoolchildren
Année de publication2018
Type de documentArticle référencé dans le Web of Science WOS:000430520700017
Auteursde Gier B., Pita-Rodriguez G. M., Campos-Ponce M., van de Bor M., Chamnan C., Junco-Diaz R., Doak C. M., Fiorentino Marion, Kuong K., Angel-Nunez F., Parker M. E., Perignon M., Rojas-Rivero L., Berger Jacques, Polman K., Wieringa Franck.
SourceActa Tropica, 2018, 182, p. 124-127. ISSN 0001-706X
RésuméThe objective of this study was to assess whether soil-transmitted helminth (STH) infections are associated with systemic and local intestinal inflammation in school-age children. In two studies in schoolchildren in Cuba (N = 1389) and in Cambodia (N = 2471), STH infections and calprotectin concentrations were measured in stool samples and acute phase proteins C-reactive protein (CRP) and alpha-1 acid glycoprotein (AGP) were measured in blood. Associations between STH infections and elevated concentrations of CRP, AGP and calprotectin were estimated using multiple logistic regression. The prevalence of elevated CRP concentration (>= 5 mg/L) was 5.4% in both populations. Elevated AGP (>= 1 g/L) was found in 39.5% of the Cambodian children and 11.3% of the Cuban children. Fecal calprotectin was elevated (>= 50 mg/kg) in 9.4% of the Cambodian children and 3.7% of the Cuban children. STH infections in Cuba were mainly due to Ascaris lumbricoides and Trichuris trichiura, with prevalences of 5.2% and 3.2%, respectively. In Cambodia, hookworm was the most prevalent species (16.3%). We found no significant associations between elevated concentrations of either acute phase proteins or fecal calprotectin and STH infections. We observed a trend towards an inverse association between elevated CRP and STH infections in both studies. STH infections are not associated with either local intestinal or systemic inflammation. The trend towards less elevated CRP concentration in STH infections may indicate a reduced risk of metabolic inflammatory diseases, which merits further investigation.
Plan de classementEntomologie médicale / Parasitologie / Virologie [052] ; Santé : généralités [050] ; Nutrition, alimentation [054]
Descr. géo.CUBA ; CAMBODGE
LocalisationFonds IRD [F B010072772]
Identifiant IRDfdi:010072772
Lien permanenthttp://www.documentation.ird.fr/hor/fdi:010072772

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