Publications des scientifiques de l'IRD

Fiorentino Marion, Perignon M., Kuong K., Chamnan C., Berger Jacques, Wieringa Franck. (2018). Subclinical inflammation affects iron and vitamin A but not zinc status assessment in Senegalese children and Cambodian children and women [+ Erratum in Public Health Nutrition.2018, vol. 21, no 11, p. 2160]. Public Health Nutrition, 21 (7), p. 1266-1277 [+ Erratum in Public Health Nutrition.2018, vol. 21, no 11, p. 2160]. ISSN 1368-9800.

Titre du document
Subclinical inflammation affects iron and vitamin A but not zinc status assessment in Senegalese children and Cambodian children and women [+ Erratum in Public Health Nutrition.2018, vol. 21, no 11, p. 2160]
Année de publication
2018
Type de document
Article référencé dans le Web of Science WOS:000430065800007
Auteurs
Fiorentino Marion, Perignon M., Kuong K., Chamnan C., Berger Jacques, Wieringa Franck
Source
Public Health Nutrition, 2018, 21 (7), p. 1266-1277 [+ Erratum in Public Health Nutrition.2018, vol. 21, no 11, p. 2160] ISSN 1368-9800
Objective: To assess the impact of the acute-phase response (APR) during inflammation on Fe, Zn and vitamin A biomarkers to allow accurate evaluation of micronutrient status in populations. Design: Ferritin (FER), soluble transferrin receptor (TfR), retinol-binding protein (RBP), Zn, alpha-acid glycoprotein and C-reactive protein concentrations were measured. Correction factors (CF) for each biomarker were calculated as the ratio for groups at different stages of inflammation v. the reference group without inflammation. Setting/Subjects: Senegalese (n 594) and Cambodian schoolchildren (n 2471); Cambodian women of reproductive age (n 2117). Results: TfR was higher during the incubation phase (CF=1.17) and lower during early and late convalescence (CF=0.87 and 0.78). FER was higher during all phases (CF=0.83, 0.48 and 0.65, respectively). RBP was higher during incubation (CF=0.88) and lower during early convalescence (CF=1.21). No effect of inflammation on Zn status was found. Conclusions: Inflammation led to overestimation of Fe status and underestimation of vitamin A status. The response of the biomarker for vitamin A status to inflammation depended on the vitamin A status of the populations. Surprisingly, the assessment of Zn status was hardly affected by inflammation. Different phases of the APR had opposite effects on the assessment of Fe status using TfR. More research is needed to define the correct methods to adjust for inflammation in nutritional studies.
Plan de classement
Santé : généralités [050] ; Nutrition, alimentation [054]
Description Géographique
SENEGAL ; CAMBODGE
Localisation
Fonds IRD [F B010072757]
Identifiant IRD
fdi:010072757
Contact