%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Pasquier, E.
%A Kunda, J.
%A Beaudrap, Pierre de
%A Loyse, A.
%A Temfack, E.
%A Molloy, S. F.
%A Harrison, T. S.
%A Lortholary, O.
%T Long-term mortality and disability in cryptococcal meningitis : a systematic literature review
%D 2018
%L fdi:010072681
%G ENG
%J Clinical Infectious Diseases
%@ 1058-4838
%K cryptococcal meningitis ; long-term outcome ; mortality ; disability ; risk ; factors
%M ISI:000427897000025
%N 7
%P 1122-1132
%R 10.1093/cid/cix870
%U https://www.documentation.ird.fr/hor/fdi:010072681
%> https://www.documentation.ird.fr/intranet/publi/2018/04/010072681.pdf
%V 66
%W Horizon (IRD)
%X Cryptococcal meningitis (CM) is the primary cause of meningitis in adults with human immunodeficiency virus (HIV) infection and an emerging disease in HIV-seronegative individuals. No literature review has studied the long-term outcome of CM. We performed a systematic review on the long-term (>= 3-month) impact of CM (Cryptococcus neoformans and Cryptococcus gattii) on mortality and disability in HIV-infected and non-HIV-infected adults. Although the quality of current evidence is limited, the long-term impact of CM on survival and disability seems to be high. One-year mortality ranged from 13% in an Australian non-HIV-infected C. gattii-infected cohort to 78% in a Malawian HIV-infected cohort treated with fluconazole monotherapy. One-year impairment proportions among survivors ranged from 19% in an Australian C. gattii cohort to >70% in a Taiwanese non-HIV- and HIV-infected cohorts. Ongoing early therapeutic interventions, early detection of impairments and access to rehabilitation services may significantly improve patients' survival and quality of life.
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