@article{fdi:010072681, title = {{L}ong-term mortality and disability in cryptococcal meningitis : a systematic literature review}, author = {{P}asquier, {E}. and {K}unda, {J}. and {B}eaudrap, {P}ierre de and {L}oyse, {A}. and {T}emfack, {E}. and {M}olloy, {S}. {F}. and {H}arrison, {T}. {S}. and {L}ortholary, {O}.}, editor = {}, language = {{ENG}}, abstract = {{C}ryptococcal meningitis ({CM}) is the primary cause of meningitis in adults with human immunodeficiency virus ({HIV}) infection and an emerging disease in {HIV}-seronegative individuals. {N}o literature review has studied the long-term outcome of {CM}. {W}e performed a systematic review on the long-term (>= 3-month) impact of {CM} ({C}ryptococcus neoformans and {C}ryptococcus gattii) on mortality and disability in {HIV}-infected and non-{HIV}-infected adults. {A}lthough the quality of current evidence is limited, the long-term impact of {CM} on survival and disability seems to be high. {O}ne-year mortality ranged from 13% in an {A}ustralian non-{HIV}-infected {C}. gattii-infected cohort to 78% in a {M}alawian {HIV}-infected cohort treated with fluconazole monotherapy. {O}ne-year impairment proportions among survivors ranged from 19% in an {A}ustralian {C}. gattii cohort to >70% in a {T}aiwanese non-{HIV}- and {HIV}-infected cohorts. {O}ngoing early therapeutic interventions, early detection of impairments and access to rehabilitation services may significantly improve patients' survival and quality of life.}, keywords = {cryptococcal meningitis ; long-term outcome ; mortality ; disability ; risk ; factors}, booktitle = {}, journal = {{C}linical {I}nfectious {D}iseases}, volume = {66}, numero = {7}, pages = {1122--1132}, ISSN = {1058-4838}, year = {2018}, DOI = {10.1093/cid/cix870}, URL = {https://www.documentation.ird.fr/hor/fdi:010072681}, }