@article{fdi:010072667, title = {{E}volved dependence in response to cancer}, author = {{T}homas, {F}. and {K}areva, {I}. and {R}aven, {N}. and {H}amede, {R}. and {P}ujol, {P}. and {R}oche, {B}enjamin and {U}jvari, {B}.}, editor = {}, language = {{ENG}}, abstract = {{E}volved dependence is a process through which one species becomes 'dependent' on another following a long evolutionary history of interaction. {T}his happens when adaptations selected in the first species for interacting lead to fitness costs when the second species is not encountered. {E}volved dependence is frequent in host-parasite interactions, where hosts may achieve a higher fitness in the presence of the parasite than in its absence. {S}ince oncogenic manifestations are (i) ubiquitous across multicellular life, (ii) involved in parasitic-like interactions with their hosts, and (iii) have effectively driven the selection of numerous adaptations, it is possible that multicellular organisms display evolved dependence in response to oncogenic processes. {W}e provide a comprehensive overview of the topic, including the implications for cancer prevention and treatment.}, keywords = {}, booktitle = {}, journal = {{T}rends in {E}cology and {E}volution}, volume = {33}, numero = {4}, pages = {269--276}, ISSN = {0169-5347}, year = {2018}, DOI = {10.1016/j.tree.2018.01.012}, URL = {https://www.documentation.ird.fr/hor/fdi:010072667}, }