@article{fdi:010072660,
  title = {{R}andomised controlled trial to test the effectiveness of a locally-produced ready-to-use supplementary food ({RUSF}) in preventing growth faltering and improving micronutrient status for children under two years in {C}ambodia : a study protocol},
  author = {{B}org, {B}. and {M}ihrshahi, {S}. and {G}riffin, {M}. and {S}ok, {D}. and {C}hhoun, {C}. and {L}aillou, {A}. and {B}erger, {J}acques and {W}ieringa, {F}ranck},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {E}xisting ready-to-use supplementary and therapeutic foods ({RUSF}s and {RUTF}s) have had limited acceptance and effectiveness in {C}ambodia. {T}his has hampered the treatment and prevention of child malnutrition. {A}n innovative, locally produced, multiple micronutrient fortified lipid-based nutrient supplement ({LNS}) has been developed for use as an {RUSF}. {U}nlike most {RUSF}s, which contain milk, this product contains fish as the animal protein. {F}ew {RUSF}s have been formulated using non-milk animal-source foods and they have not been widely tested. {A}n acceptability trial that was conducted on this novel {RUSF} in {J}une 2015 demonstrated that children will eat the {RUSF} and that caregivers will feed it to their children. {T}he current trial aims to evaluate the effectiveness of the {RUSF} in preventing growth faltering and improving micronutrient status in {C}ambodian children. {M}ethods and analysis: {T}his trial is a six-month, prospective, cluster randomised, non-blinded controlled trial among infants in peri-urban {P}hnom {P}enh. {T}he trial aims to establish the superiority of the novel {RUSF}, compared to three alternatives ({C}orn-{S}oy {B}lend {P}lus {P}lus ({CSB}++) and {S}prinkles micronutrient powders as active comparators, and the unimproved diet as a control). {T}he allocation ratio is 1: 1. {H}ealthy children ({N} = 540) aged six to eleven months will be recruited. {D}ata will be collected at baseline, and monthly thereafter for a period of six months. {P}articipants will be provided with a monthly supply of the food to which their village has been allocated. {D}iscussion: {T}here is an urgent need to develop locally produced and culturally acceptable {RUSF}s, and to compare these with existing options in terms of their potential for preventing malnutrition, in {C}ambodia and elsewhere. {T}his trial will contribute much-needed data on the effectiveness of supplementary foods with an animal-source food other than milk, by comparing a novel {RUSF} based on fish to one that uses milk ({CSB}++). {M}oreover, it will deepen the understanding of the impact of multiple micronutrients provided with or without macronutrients, by comparing the novel {RUSF} and {CSB}++, which combine macronutrients with multiple micronutrients, to {S}prinkles, which contains no macronutrients. {I}n addition, it will augment the body of evidence from {A}sia.},
  keywords = {{R}eady-to-use supplementary food ({RUSF}) ; {L}ipid-based nutrient supplement ; ({LNS}) ; {C}hildhood malnutrition ; {G}rowth faltering ; {C}orn-{S}oy {B}lend {P}lus ; {P}lus ({CSB} plus plus ) ; {S}upercereal {P}lus ; {S}prinkles micronutrient ; powders ; {C}ambodia ; {CAMBODGE}},
  booktitle = {},
  journal = {{N}utrition {J}ournal},
  volume = {17},
  numero = {},
  pages = {art. 39 [11 p.]},
  ISSN = {1475-2891},
  year = {2018},
  DOI = {10.1186/s12937-018-0346-x},
  URL = {https://www.documentation.ird.fr/hor/fdi:010072660},
}