@article{fdi:010072630,
  title = {{D}isentangling complex parasite interactions : protection against cerebral malaria by one helminth species is jeopardized by co-infection with another},
  author = {{A}bbate, {J}.{L}. and {E}zenwa, {V}.{O}. and {G}u{\'e}gan, {J}ean-{F}ran{\c{c}}ois and {C}hoisy, {M}arc and {N}acher, {M}. and {R}oche, {B}enjamin},
  editor = {},
  language = {{ENG}},
  abstract = {{M}ulti-species interactions can often have non-intuitive consequences. {H}owever, the study of parasite interactions has rarely gone beyond the effects of pairwise combinations of species, and the outcomes of multi-parasite interactions are poorly understood. {W}e investigated the effects of co-infection by four gastrointestinal helminth species on the development of cerebral malaria among {P}lasmodium falciparum-infected patients. {W}e characterized associations among the helminth parasite infra-community, and then tested for independent (direct) and co-infection dependent (indirect) effects of helminths on cerebral malaria risk. {W}e found that infection by {A}scaris lumbricoides and {T}richuris trichiura were both associated with direct reductions in cerebral malaria risk. {H}owever, the benefit of {T}. trichiura infection was halved in the presence of hookworm, revealing a strong indirect effect. {O}ur study suggests that the outcome of interactions between two parasite species can be significantly modified by a third, emphasizing the critical role that parasite community interactions play in shaping infection outcomes.},
  keywords = {{THAILANDE}},
  booktitle = {},
  journal = {{P}los {N}eglected {T}ropical {D}iseases},
  volume = {12},
  numero = {5},
  pages = {e0006483},
  ISSN = {1935-2735},
  year = {2018},
  DOI = {10.1371/journal.pntd.0006483},
  URL = {https://www.documentation.ird.fr/hor/fdi:010072630},
}