%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Sabbagh, A.
%A Sonon, P.
%A Sadissou, I.
%A Mendes, C. T.
%A Garcia, André
%A Donadi, E. A.
%A Courtin, David
%T The role of HLA-G in parasitic diseases
%D 2018
%L fdi:010072479
%G ENG
%J HLA
%@ 2059-2302
%K echinococcosis ; genetics ; HLA-G ; immune system ; leishmaniosis ; malaria ; parasite ; toxoplasmosis ; trypanosomiasis
%K AFRIQUE SUBSAHARIENNE ; AMERIQUE LATINE
%M ISI:000427474300001
%N 4
%P 255-270
%R 10.1111/tan.13196
%U https://www.documentation.ird.fr/hor/fdi:010072479
%> https://www.documentation.ird.fr/intranet/publi/2018/04/010072479.pdf
%V 91
%W Horizon (IRD)
%X Little attention has been devoted to the role of HLA-G gene and molecule on parasitic disorders, and the available studies have focused on malaria, African and American trypanosomiasis, leishmaniosis, toxoplasmosis and echinococcosis. After reporting a brief description regarding the role of the cells of innate and adaptive immune system against parasites, we reviewed the major features of the HLA-G gene and molecule and the role of HLA-G on the major cells of immune system. Increased levels of soluble HLA-G (sHLA-G) have been observed in patients presenting toxoplasmosis and in the active phase of echinococcosis. In addition, increased sHLA-G has also been associated with increased susceptibility to malaria and increased susceptibility to develop human African trypanosomiasis (HAT). In contrast, decreased membrane-bound HLA-G has been reported in placenta of patients infected with Plasmodium falciparum and in heart and colon of patients presenting Chagas disease. The 30 untranslated region of the HLA-G gene has been the main focus of studies on malaria, HAT and Chagas disease, exhibiting distinct patterns of associations. Considering that HLA-G is an immune checkpoint molecule, inhibiting the activity of several cells of the immune system, the excessive neoexpression and the increased sHLA-G levels together with the decreased constitutive tissue expression of membrane-bound HLA-G may be detrimental to the host infected with parasite agents.
%$ 052 ; 050