@article{fdi:010072458,
  title = {{A}lternative treatment strategies to accelerate the elimination of onchocerciasis},
  author = {{B}oussinesq, {M}ichel and {F}obi, {G}. and {K}uesel, {A}. {C}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he use of alternative (or complementary) treatment strategies ({ATS}s) i.e. differing from annual community-directed treatment with ivermectin ({CDTI}) is required in some {A}frican foci to eliminate onchocerciasis by 2025. {ATS}s include vector control, biannual or pluriannual {CDTI}, better timing of {CDTI}, community-directed treatment with combinations of currently available anthelminthics or new drugs, and 'test-and-treat' ({TNT}) strategies requiring diagnosis of infection and/or contraindications to treatment for decisions on who to treat with what regimen. {T}wo {TNT} strategies can be considered. {L}oa-first {TNT}, designed for loiasis-endemic areas and currently being evaluated using a rapid test ({L}oa{S}cope), consists of identifying individuals with levels of {L}oa microfilaremia associated with a risk of post-ivermectin severe adverse events to exclude them from ivermectin treatment and in treating the rest (usually > 97%) of the population safely. {O}ncho-first {TNT} consists of testing community members for onchocerciasis before giving treatment (currently ivermectin or doxycycline) to those who are infected. {T}he choice of the {ATS} depends on the prevalences and intensities of infection with {O}nchocerca volvulus and {L}oa loa and on the relative cost-effectiveness of the strategies for the given epidemiological situation. {M}odelling can help select the optimal strategies, but field evaluations to determine the relative cost-effectiveness are urgently needed.},
  keywords = {{A}lternative treatment strategies ; {E}limination ; {M}acrofilaricidal drugs ; {N}ew treatments ; {O}nchocerciasis ; {T}est-and-{T}reat strategies ; {AFRIQUE} {SUBSAHARIENNE}},
  booktitle = {},
  journal = {{I}nternational {H}ealth},
  volume = {10},
  numero = {1},
  pages = {i40--i48},
  ISSN = {1876-3413},
  year = {2018},
  DOI = {10.1093/inthealth/ihx054},
  URL = {https://www.documentation.ird.fr/hor/fdi:010072458},
}