Publications des scientifiques de l'IRD

Kamgno J., Nana-Djeunga H. C., Pion Sébastien, Chesnais Cédric, Klion A. D., Mackenzie C. D., Nutman T. B., Boussinesq Michel. (2018). Operationalization of the test and not treat strategy to accelerate the elimination of onchocerciasis and lymphatic filariasis in Central Africa. International Health, 10 (1), p. i49-i53. ISSN 1876-3413.

Titre du document
Operationalization of the test and not treat strategy to accelerate the elimination of onchocerciasis and lymphatic filariasis in Central Africa
Année de publication
2018
Type de document
Article référencé dans le Web of Science WOS:000426845000009
Auteurs
Kamgno J., Nana-Djeunga H. C., Pion Sébastien, Chesnais Cédric, Klion A. D., Mackenzie C. D., Nutman T. B., Boussinesq Michel
Source
International Health, 2018, 10 (1), p. i49-i53 ISSN 1876-3413
After 30 years of treatment with Mectizan (ivermectin), cutaneous and ocular complications of Onchocerca volvulus infection are now scarce in endemic communities. Indeed, transmission has been interrupted and the volvulus- associated disease has disappeared in some African foci. Despite this success, onchocerciasis elimination in Loa loa co-endemic areas is still constrained by severe adverse events (SAEs) occurring after ivermectin treatment in some individuals harbouring very high L. loa microfilaremia. One approach towards the prevention of these SAEs is to identify individuals with high L. loa microfilaremia and exclude them from ivermectin treatment. The development of the LoaScope has provided the tool that underlies this test and not treat (TaNT) strategy. The first successful TaNT campaign was conducted in a L. loa highly endemic focus in Cameroon in 2015 without any SAEs. To accomplish this within a research setting, 60 people were deployed for this campaign, making this 'research' strategy not sustainable from a cost perspective. We describe here a way of reducing the cost of the TaNT strategy with a smaller team (three people) selected within affected communities. We also suggest the organization of a TaNT campaign in affected countries.
Plan de classement
Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
CAMEROUN ; AFRIQUE CENTRALE
Localisation
Fonds IRD [F B010072454]
Identifiant IRD
fdi:010072454
Contact