@article{fdi:010072380,
  title = {{F}amilial aggregation and heritability of {L}oa loa microfilaremia},
  author = {{E}yebe, {S}. and {S}abbagh, {A}. and {P}ion, {S}{\'e}bastien and {N}ana-{D}jeunga, {H}. {C}. and {K}amgno, {J}. and {B}oussinesq, {M}ichel and {C}hesnais, {C}{\'e}dric},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground. {F}or a given prevalence of {L}oa loa microfilaremia, the proportion of people with high densities varies significantly between communities. {W}e hypothesized that this variation is related to the existence of familial clusters of hypermicrofilaremic individuals that would be the consequence of a genetic predisposition to present high {L}. loa microfilarial densities. {M}ethods. {A} familial study was performed in 10 villages in the {O}kola {H}ealth {D}istrict of {C}ameroon. {I}ntrafamilial correlation coefficients and heritability estimates were assessed for both the presence of {L}. loa microfilaremia and individual microfilarial densities by controlling for age, sex, {M}ansonella perstans coinfection, and household effects. {R}esults. {P}edigrees were constructed for 1126 individuals. {A} significant familial susceptibility to be microfilaremic for {L}. loa was found for first-degree relatives (rho = 0.08, {P}<.05; heritability = 0.23). {R}egarding individual microfilarial densities, a significant familial aggregation was demonstrated (rho = 0.36 for first-degree and 0.27 for second-degree relatives). {F}or first-degree relatives, the highest coefficient was found between mothers and daughters (rho = 0.57). {T}he overall heritability estimate for {L}. loa microfilarial density was 0.24 ({P}=.003). {C}onclusions. {A} significant genetic component governs {L}. loa microfilarial density. {T}his supports the hypothesis that a genetic predisposition to be hypermicrofilaremic exists, leading to the presence of familial clusters of individuals at risk for postivermectin severe adverse events. {T}his finding should be taken into account while developing sampling strategies (including a household-level sampling) to identify villages where community-directed treatment with ivermectin cannot be applied.},
  keywords = {filariasis ; loiasis ; heritability ; familial susceptibility ; {A}frica ; {CAMEROUN}},
  booktitle = {},
  journal = {{C}linical {I}nfectious {D}iseases},
  volume = {66},
  numero = {5},
  pages = {751--757},
  ISSN = {1058-4838},
  year = {2018},
  DOI = {10.1093/cid/cix877},
  URL = {https://www.documentation.ird.fr/hor/fdi:010072380},
}