@article{fdi:010072379,
  title = {{L}itsea cubeba leaf essential oil from {V}ietnam : chemical diversity and its impacts on antibacterial activity},
  author = {{N}guyen, {H}. {V}. and {M}eile, {J}. {C}. and {L}ebrun, {M}ichel and {C}aruso, {D}omenico and {C}hu-{K}y, {S}. and {S}arter, {S}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he threat of bacterial resistance to antibiotics has created an urgent need to develop new antimicrobials. {T}he aim of this study was to characterize the chemical diversity of {L}itsea cubeba leaf essential oil ({EO}) and its impacts on the antibacterial activity against pathogenic bacteria. {E}ssential oils collected from seven provinces in {N}orth {V}ietnam (n=25) were characterized by their high content in either 1,8-cineole or linalool. {L}inalool-type {EO}s were more effective against the eight bacterial strains tested than 1,8-cineole-type. {O}il samples, {LC}19 (50% 1,8-cineole) and {BV}27 (94% linalool), were selected to investigate their antibacterial mechanisms against {E}scherichia coli. {A} strong bactericidal effect was observed after 4 and 2h of exposure respectively. {M}icroscopic analysis of treated {E}.coli cultures clearly showed that {EO}s caused changes in cell morphology, loss of integrity and permeability of the cell membrane, as well as {DNA} loss. {H}owever, the effects of both {EO}s were distinct. {LC}19 mostly affected cell membrane, led to a significant cell filamentation rate and altered cell width, whereas {BV}27 damaged cell membrane integrity leading to cell permeabilization and altered nucleoid morphology with the appearance of spot and visibly altered compaction. {S}ignificance and {I}mpact of the {S}tudy{T}his study aimed to characterize the chemical diversity of {L}itsea cubeba leaf essential oil ({EO}) and its impacts on its antibacterial activity. {T}wo major chemotypes (1,8-cineole or linalool rich) were identified in {N}orth {V}ietnam and both were bactericidal against several pathogenic bacteria. {A} distinct inhibitory effect of {EO} samples on {E}scherichia coli was observed. 1,8-cineole-rich sample ({LC}19) affected cell membrane, led to cell filamentation and perturbation of cell width, while the linalool-rich one ({BV}27) induced damages in the cell membrane and changes in the nucleoid morphology. {T}he study demonstrates the importance of considering chemotype variations in terms of chemical composition as well as the mode of action.},
  keywords = {antibacterial mechanism ; chemical diversity ; essential oils ; {L}itsea cubeba ; pathogenic bacteria ; {V}ietnam ; {VIET} {NAM}},
  booktitle = {},
  journal = {{L}etters in {A}pplied {M}icrobiology},
  volume = {66},
  numero = {3},
  pages = {207--214},
  ISSN = {0266-8254},
  year = {2018},
  DOI = {10.1111/lam.12837},
  URL = {https://www.documentation.ird.fr/hor/fdi:010072379},
}