@article{fdi:010072376,
  title = {{M}olecular epidemiology of dengue viruses in three provinces of {L}ao {PDR}, 2006-2010},
  author = {{C}astonguay-{V}anier, {J}. and {K}litting, {R}. and {S}engvilaipaseuth, {O}. and {P}iorkowski, {G}. and {B}aronti, {C}{\'e}cile and {S}ibounheuang, {B}. and {V}ongsouvath, {M}. and {C}hanthongthip, {A}. and {T}hongpaseuth, {S}. and {M}ayxay, {M}. and {P}hommasone, {K}. and {D}ouangdala, {P}. and {I}nthalath, {S}. and {S}ouvannasing, {P}. and {N}ewton, {P}. {N}. and de {L}amballerie, {X}. and {D}ubot {P}{\'e}r{\`e}s, {A}udrey},
  editor = {},
  language = {{ENG}},
  abstract = {{F}ew data on dengue epidemiology are available for {L}ao {PDR}. {H}ere, we provide information on the complexity of dengue epidemiology in the country, demonstrating dynamic circulation that varies over space and time, according to serotype. {W}e recruited 1,912 consenting patients presenting with {WHO} dengue criteria at {M}ahosot {H}ospital, {V}ientiane (central {L}aos), between 2006 and 2010. {B}etween 2008 and 2010, 1,413 patients with undifferentiated fever were also recruited at {L}uang {N}amtha ({LNT}) {P}rovincial {H}ospital (northern {L}aos) and 555 at {S}alavan ({SV}) {P}rovincial {H}ospital (southern {L}aos). {W}e report significant variations in {D}engue virus ({DENV}) circulation between the three sites. {P}eaks of {DENV} infection were observed in the rainy seasons, although 11% of confirmed cases in the provinces and 4.6% in the capital were detected during the dry and cool seasons (between {D}ecember and {F}ebruary). {F}our {DENV} serotypes were detected among the 867 {RT}-{PCR} positive patients: 76.9% {DENV}-1, 9.6% {DENV}-2, 7.7% {DENV}-4 and 5.3% {DENV}-3. {DENV}-1 was the predominant serotype throughout the study except in {LNT} in 2008 and 2009 when it was {DENV}-2. {B}efore {J}uly 2009, {DENV}-2 was not detected in {SV} and only rarely detected in {V}ientiane. {DENV}-3 and {DENV}-4 were commonly detected in {V}ientiane, before 2008 for {DENV}-4 and after 2009 for {DENV}-3. {T}he phylogenetic analyses of {DENV} envelope sequences suggest concurrent multiple introductions of new strains as well as active {DENV} circulation throughout {L}aos and with neighboring countries. {I}t is therefore of great importance to develop and strengthen a year-round nation-wide surveillance network in order to collect data that would allow anticipation of public health issues caused by the occurrence of large dengue outbreaks.},
  keywords = {{LAOS}},
  booktitle = {},
  journal = {{PL}o{S} {N}eglected {T}ropical {D}iseases},
  volume = {12},
  numero = {1},
  pages = {e0006203 [21p.]},
  ISSN = {1935-2735},
  year = {2018},
  DOI = {10.1371/journal.pntd.0006203},
  URL = {https://www.documentation.ird.fr/hor/fdi:010072376},
}