@article{fdi:010072373,
  title = {{E}valuating the sustainability, scalability, and replicability of an {STH} transmission interruption intervention : the {D}e{W}orm3 implementation science protocol},
  author = {{M}eans, {A}. {R}. and {A}jjampur, {S}. {S}. {R}. and {B}ailey, {R}. and {G}alactionova, {K}. and {G}wayi-{C}hore, {M}. {C}. and {H}alliday, {K}. and {I}bikounle, {M}. and {J}uvekar, {S}. and {K}alua, {K}. and {K}ang, {G}. and {L}ele, {P}. and {L}uty, {A}drian and {P}ullan, {R}. and {S}arkar, {R}. and {S}char, {F}. and {T}ediosi, {F}. and {W}einer, {B}. {J}. and {Y}ard, {E}. and {W}alson, {J}. and {D}e{W}orm3 {I}mplementation {S}cience{T}eam},
  editor = {},
  language = {{ENG}},
  abstract = {{H}ybrid trials that include both clinical and implementation science outcomes are increasingly relevant for public health researchers that aim to rapidly translate study findings into evidence- based practice. {T}he {D}e{W}orm3 {P}roject is a series of hybrid trials testing the feasibility of interrupting the transmission of soil transmitted helminths ({STH}), while conducting implementation science research that contextualizes clinical research findings and provides guidance on opportunities to optimize delivery of {STH} interventions. {T}he purpose of {D}e{W}orm3 implementation science studies is to ensure rapid and efficient translation of evidence into practice. {D}e{W}orm3 will use stakeholder mapping to identify individuals who influence or are influenced by school-based or community-wide mass drug administration ({MDA}) for {STH} and to evaluate network dynamics that may affect study outcomes and future policy development. {I}ndividual interviews and focus groups will generate the qualitative data needed to identify factors that shape, contextualize, and explain {D}e{W}orm3 trial outputs and outcomes. {S}tructural readiness surveys will be used to evaluate the factors that drive health system readiness to implement novel interventions, such as community-wide {MDA} for {STH}, in order to target change management activities and identify opportunities for sustaining or scaling the intervention. {P}rocess mapping will be used to understand what aspects of the intervention are adaptable across heterogeneous implementation settings and to identify contextually- relevant modifiable bottlenecks that may be addressed to improve the intervention delivery process and to achieve intervention outputs. {L}astly, intervention costs and incremental cost-effectiveness will be evaluated to compare the efficiency of community-wide {MDA} to standard-of-care targeted {MDA} both over the duration of the trial and over a longer elimination time horizon.},
  keywords = {},
  booktitle = {},
  journal = {{PL}o{S} {N}eglected {T}ropical {D}iseases},
  volume = {12},
  numero = {1},
  pages = {e0005988 [13 p.]},
  ISSN = {1935-2735},
  year = {2018},
  DOI = {10.1371/journal.pntd.0005988},
  URL = {https://www.documentation.ird.fr/hor/fdi:010072373},
}