@article{fdi:010072371,
  title = {{A}ssessing dengue transmission risk and a vector control intervention using entomological and immunological indices in {T}hailand : study protocol for a cluster-randomized controlled trial [+ {C}orrection 2018, vol. 19, p. 703]},
  author = {{O}vergaard, {H}. {J}. and {P}ientong, {C}. and {T}haewnongiew, {K}. and {B}angs, {M}. {J}. and {E}kalaksananan, {T}. and {A}romseree, {S}. and {P}hanitchat, {T}. and {P}hanthanawiboon, {S}. and {F}ustec, {B}{\'e}n{\'e}dicte and {C}orbel, {V}incent and {C}erqueira, {D}. and {A}lexander, {N}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {D}engue fever is the most common and widespread mosquito-borne arboviral disease in the world. {T}here is a compelling need for cost-effective approaches and practical tools that can reliably measure real-time dengue transmission dynamics that enable more accurate and useful predictions of incidence and outbreaks. {S}ensitive surveillance tools do not exist today, and only a small handful of new control strategies are available. {V}ector control remains at the forefront for combating dengue transmission. {H}owever, the effectiveness of many current vector control interventions is fraught with inherent weaknesses. {N}o single vector control method is effective enough to control both vector populations and disease transmission. {E}valuations of novel larval and adult control interventions are needed. {M}ethods/design: {A} cluster-randomized controlled trial will be carried out between 2017 and 2019 in urban community clusters in {K}hon {K}aen and {R}oi {E}t cities, northeastern {T}hailand. {T}he effectiveness of a pyriproxyfen/spinosad combination treatment of permanent water storage containers will be evaluated on epidemiological and entomological outcomes, including dengue incidence, number of female adult dengue vectors infected or not infected with dengue virus ({DENV}), human exposure to {A}edes mosquito bites, and several other indices. {T}hese indices will also be used to develop predictive models for dengue transmission and impending outbreaks. {E}pidemiological and entomological data will be collected continuously for 2 years, with the intervention implemented after 1 year. {D}iscussion: {T}he aims of the trial are to simultaneously evaluate the efficacy of an innovative dengue vector control intervention and developing predictive dengue models. {A}ssessment of human exposure to mosquito bites by detecting antibodies generated against {A}edes saliva proteins in human blood samples has, so far, not been applied in dengue epidemiological risk assessment and disease surveillance methodologies. {L}ikewise, {DENV} detection in mosquitoes (adult and immature stages) has not been used in any practical way for routine disease surveillance strategies. {T}he integration of multiple outcome measures will assist health authorities to better predict outbreaks for planning and applying focal and timely interventions. {T}he trial outcomes will not only be important for {T}hailand, but also for the entire {S}outheast {A}sian region and further afield.},
  keywords = {{D}engue monitoring ; {E}ntomology ; {I}mmunology ; {D}engue index ; {R}isk assessment ; {V}ector control ; {THAILANDE}},
  booktitle = {},
  journal = {{T}rials},
  volume = {19},
  numero = {},
  pages = {art. no 122 [ 19 ] + correction art. no 703 [1 p.]},
  ISSN = {1745-6215},
  year = {2018},
  DOI = {10.1186/s13063-018-2490-1},
  URL = {https://www.documentation.ird.fr/hor/fdi:010072371},
}