@article{fdi:010072340,
  title = {{A}nti-{H}elicobacter pylori properties of the ant-venom peptide bicarinalin},
  author = {{G}uzman, {J}. and {T}ene, {N}. and {T}ouchard, {A}. and {C}astillo, {D}. and {B}elkhelfa, {H}. and {H}addioui-{H}babi, {L}. and {T}reilhou, {M}. and {S}auvain, {M}ichel},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he venom peptide bicarinalin, previously isolated from the ant {T}etramorium bicarinatum, is an antimicrobial agent with a broad spectrum of activity. {I}n this study, we investigate the potential of bicarinalin as a novel agent against {H}elicobacter pylori, which causes several gastric diseases. {F}irst, the effects of synthetic bicarinalin have been tested against {H}elicobacter pylori: one {ATCC} strain, and forty-four isolated from stomach ulcer biopsies of {P}eruvian patients. {T}hen the cytoxicity of bicarinalin on human gastric cells and murine peritoneal macrophages was measured using {XTT} and {MTT} assays, respectively. {F}inally, the preventive effect of bicarinalin was evaluated by scanning electron microscopy using an adherence assay of {H}. pylori on human gastric cells treated with bicarinalin. {T}his peptide has a potent antibacterial activity at the same magnitude as four antibiotics currently used in therapies against {H}. pylori. {B}icarinalin also inhibited adherence of {H}. pylori to gastric cells with an {IC}50 of 0.12 g<bold>m{L}</bold>-1 and had low toxicity for human cells. {S}canning electron microscopy confirmed that bicarinalin can significantly decrease the density of {H}. pylori on gastric cells. {W}e conclude that {B}icarinalin is a promising compound for the development of a novel and effective anti-{H}. pylori agent for both curative and preventive use.},
  keywords = {bicarinalin ; antimicrobial peptide ; {H}elicobacter pylori ; gastric cells ; bacterial adhesion ; {SEM}},
  booktitle = {},
  journal = {{T}oxins},
  volume = {10},
  numero = {1},
  pages = {art. 21 [10 p.]},
  ISSN = {2072-6651},
  year = {2018},
  DOI = {10.3390/toxins10010021},
  URL = {https://www.documentation.ird.fr/hor/fdi:010072340},
}